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10.2169/internalmedicine.56.7923

http://scihub22266oqcxt.onion/10.2169/internalmedicine.56.7923
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suck abstract from ncbi


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pmid28458315
      Intern+Med 2017 ; 56 (9 ): 1071-1077
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  • Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an Early-onset Case in an Obese Patient #MMPMID28458315
  • D Hayashi R ; Yamaoka M ; Nishizawa H ; Fukuda S ; Fujishima Y ; Kimura T ; Kozawa J ; Kita S ; Matsuoka TA ; Otsuki M ; Imagawa A ; Ichida K ; Taniguchi A ; Maeda N ; Funahashi T ; Shimomura I
  • Intern Med 2017[]; 56 (9 ): 1071-1077 PMID28458315 show ga
  • A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty tophi with bone erosion and destruction, resulting in gait disturbance for 6 years after the early onset of gout at 21 years of age. His hyperuricemia was associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2 gene. In addition, multiple gouty tophi with bone erosion and destruction might have been caused by hypoadiponectinemia and the elevation of the patient' s pro-inflammatory cytokine (IL-1?) level with the accumulation of visceral fat. In this case, bone and Ga-67 scintigraphy were useful for detecting the location and magnitude of gouty tophi.
  • |Adult [MESH]
  • |Arthritis, Gouty/*complications/diagnostic imaging/*drug therapy [MESH]
  • |Cytokines/blood [MESH]
  • |Febuxostat/*therapeutic use [MESH]
  • |Gout Suppressants/*therapeutic use [MESH]
  • |Hand/diagnostic imaging/physiopathology [MESH]
  • |Humans [MESH]
  • |Hyperuricemia/*complications/*drug therapy [MESH]
  • |Knee Joint/diagnostic imaging/physiopathology [MESH]
  • |Male [MESH]
  • |Obesity/complications [MESH]


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