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2017 ; 56
(9
): 1071-1077
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Multiple Gouty Tophi with Bone Erosion and Destruction: A Report of an
Early-onset Case in an Obese Patient
#MMPMID28458315
D Hayashi R
; Yamaoka M
; Nishizawa H
; Fukuda S
; Fujishima Y
; Kimura T
; Kozawa J
; Kita S
; Matsuoka TA
; Otsuki M
; Imagawa A
; Ichida K
; Taniguchi A
; Maeda N
; Funahashi T
; Shimomura I
Intern Med
2017[]; 56
(9
): 1071-1077
PMID28458315
show ga
A 27 year-old severely obese man (BMI, 35.1) had hyperuricemia and multiple gouty
tophi with bone erosion and destruction, resulting in gait disturbance for 6
years after the early onset of gout at 21 years of age. His hyperuricemia was
associated with hyperinsulinemia in obesity and a genetic variant of the ABCG2
gene. In addition, multiple gouty tophi with bone erosion and destruction might
have been caused by hypoadiponectinemia and the elevation of the patient' s
pro-inflammatory cytokine (IL-1?) level with the accumulation of visceral fat. In
this case, bone and Ga-67 scintigraphy were useful for detecting the location and
magnitude of gouty tophi.