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10.1016/j.celrep.2016.10.061 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.10.061 C5478386!5478386!27851967     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 17 (8): 2042-59 Nephropedia Template TP {{tp|p=27851967|t=2016. A Compendium of Chromatin Contact Maps Reveal Spatially Active Regions in the Human Genome |pdf=|usr=}}{{27851967}} gab.com Text A Compendium of Chromatin Contact Maps Reveal Spatially Active Regions in the Human Genome JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27851967 #FOAvip The three-dimensional configuration of DNA is integral to all nuclear processes in eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide chromosome conformation capture studies have uncovered features of chromatin organization in cultured cells, but genome architecture in human tissues has yet to be explored. Here, we report the most comprehensive survey to date of chromatin organization in human tissues. Through integrative analysis of chromatin contact maps in 21 primary human tissues and cell types, we found topologically associating domains highly conserved in different tissues. We also discover genomic regions that exhibit unusually high levels of local chromatin interactions. These frequently interacting regions (FIREs) are enriched for super-enhancers and are near tissue-specifically expressed genes. They display strong tissue-specificity in local chromatin interactions. Additionally, FIRE formation is partially dependent on CTCF and the Cohesin complex. We further show that FIREs can help annotate function of non-coding sequence variants. Twit Text FOAVip A Compendium of Chromatin Contact Maps Reveal Spatially Active Regions in the Human Genome ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27851967 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27851967 #FOAvip English Wikipedia <ref>{{Cite pmid|27851967}}</ref> A Compendium of Chromatin Contact Maps Reveal Spatially Active Regions in the Human Genome #MMPMID27851967 Schmitt AD; Hu M; Jung I; Xu Z; Qiu Y; Tan CL; Li Y; Lin S; Lin Y; Barr CL; Ren B Cell Rep 2016[Nov]; 17 (8): 2042-59 PMID27851967show ga The three-dimensional configuration of DNA is integral to all nuclear processes in eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide chromosome conformation capture studies have uncovered features of chromatin organization in cultured cells, but genome architecture in human tissues has yet to be explored. Here, we report the most comprehensive survey to date of chromatin organization in human tissues. Through integrative analysis of chromatin contact maps in 21 primary human tissues and cell types, we found topologically associating domains highly conserved in different tissues. We also discover genomic regions that exhibit unusually high levels of local chromatin interactions. These frequently interacting regions (FIREs) are enriched for super-enhancers and are near tissue-specifically expressed genes. They display strong tissue-specificity in local chromatin interactions. Additionally, FIRE formation is partially dependent on CTCF and the Cohesin complex. We further show that FIREs can help annotate function of non-coding sequence variants. äA Compendium of Chromatin Contact Maps Reveal Spatially Active Regions(epmc).pdf DeepDyve Pubget Overpricing