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10.1097/MD.0000000000007218

http://scihub22266oqcxt.onion/10.1097/MD.0000000000007218
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suck abstract from ncbi


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pmid28614271
      Medicine+(Baltimore) 2017 ; 96 (24 ): e7218
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  • Serum anti-PLA2R antibody and glomerular PLA2R deposition in Chinese patients with membranous nephropathy: A cross-sectional study #MMPMID28614271
  • Pang L ; Zhang AM ; Li HX ; Du JL ; Jiao LL ; Duan N ; Liu Y ; Yu D
  • Medicine (Baltimore) 2017[Jun]; 96 (24 ): e7218 PMID28614271 show ga
  • M-type phospholipase A2 receptor (PLA2R) is the major target antigen in primary membranous nephropathy (PMN). Previous studies have evaluated the diagnostic value of serum anti-PLA2R antibody. However, the correlation of serum anti-PLA2R antibody and glomerular PLA2R deposition, and their association with clinical characteristics need to be further evaluated.A total of 136 patients were involved as inception group because serum anti-PLA2R antibody and glomerular PLA2R antigen were simultaneously measured. We examined serum anti-PLA2R antibody by ELISA and glomerular PLA2R deposition by immunofluorescence assay.Positive serum anti-PLA2R antibody and glomerular PLA2R deposition were seen in 58.8% (80/136) and 95.6% (130/136) patients, respectively (P?
  • |Autoantibodies/*blood [MESH]
  • |Biomarkers/metabolism [MESH]
  • |China [MESH]
  • |Creatinine/blood [MESH]
  • |Cross-Sectional Studies [MESH]
  • |Enzyme-Linked Immunosorbent Assay [MESH]
  • |Fluorescent Antibody Technique [MESH]
  • |Glomerular Filtration Rate [MESH]
  • |Glomerulonephritis, Membranous/drug therapy/*metabolism/pathology [MESH]
  • |Humans [MESH]
  • |Immunoglobulin G/*metabolism [MESH]
  • |Kidney/*metabolism/pathology [MESH]
  • |Proteinuria/drug therapy/metabolism/pathology [MESH]
  • |Receptors, Phospholipase A2/*metabolism [MESH]
  • |Retrospective Studies [MESH]
  • |Sensitivity and Specificity [MESH]


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