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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2017 ; 96
(24
): e7218
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Serum anti-PLA2R antibody and glomerular PLA2R deposition in Chinese patients
with membranous nephropathy: A cross-sectional study
#MMPMID28614271
Pang L
; Zhang AM
; Li HX
; Du JL
; Jiao LL
; Duan N
; Liu Y
; Yu D
Medicine (Baltimore)
2017[Jun]; 96
(24
): e7218
PMID28614271
show ga
M-type phospholipase A2 receptor (PLA2R) is the major target antigen in primary
membranous nephropathy (PMN). Previous studies have evaluated the diagnostic
value of serum anti-PLA2R antibody. However, the correlation of serum anti-PLA2R
antibody and glomerular PLA2R deposition, and their association with clinical
characteristics need to be further evaluated.A total of 136 patients were
involved as inception group because serum anti-PLA2R antibody and glomerular
PLA2R antigen were simultaneously measured. We examined serum anti-PLA2R antibody
by ELISA and glomerular PLA2R deposition by immunofluorescence assay.Positive
serum anti-PLA2R antibody and glomerular PLA2R deposition were seen in 58.8%
(80/136) and 95.6% (130/136) patients, respectively (P?.001). Proteinuria,
serum total protein, serum albumin, serum creatinine, and estimated glomerular
filtration rate (eGFR) had significant differences between patients with serum
anti-PLA2R antibody and those without. Serum anti-PLA2R antibody levels were
correlated with serum albumin, serum creatinine, eGFR, and proteinuria.
Glomerular PLA2R deposition intensities were weakly correlated with proteinuria.
Unexpectedly, there was a positive correlation rather than a negative correlation
between glomerular PLA2R deposition intensity and eGFR.In conclusion, serum
anti-PLA2R antibody is more closely correlated with disease activity and renal
function than glomerular PLA2R deposition.