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2017 ; 96
(24
): e7163
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The prevalence of heterotopic ossification among patients after cervical
artificial disc replacement: A systematic review and meta-analysis
#MMPMID28614250
Kong L
; Ma Q
; Meng F
; Cao J
; Yu K
; Shen Y
Medicine (Baltimore)
2017[Jun]; 96
(24
): e7163
PMID28614250
show ga
BACKGROUND: Prevalence estimates of heterotopic ossification (HO) following
cervical artificial disc replacement (ADR) varied widely in previous studies. We
conducted a systematic review and meta-analysis to summarize its point
prevalence. METHODS: Electronic searches of PubMed, Web of Science, Embase, and
Cochrane Library databases were conducted to identify studies that reported
prevalence of HO. Definitions of HO and severe HO were based on McAfee grading
system. Random-effects model was used to estimate the pooled prevalence. We
conducted subgroup analyses according to the different length of follow-up time,
and performed univariate metaregression analyses to explore the effects of
potential variables on the overall prevalence. RESULTS: A total of 38 studies
were included in this study. The pooled data showed that the prevalence of HO
after cervical ADR within the 1 to 2 years, 2 to 5 years, and 5 to10 years of
follow-up was 38.0% (95% confidence interval [CI], 30.2%-46.5%), 52.6% (95% CI,
43.1%-61.9%), and 53.6% (95% CI, 40.0%-66.7%), respectively, while the prevalence
of severe HO was 10.9% (95% CI, 9.0%-13.2%), 22.2% (95% CI, 15.5%-30.7%), and
47.5% (95% CI, 30.0%-65.8%), respectively. Follow-up time was positively
associated with the prevalence of severe HO (P?.01), and the 1-month growth of
mean follow-up went with 0.63% increase of severe HO. CONCLUSION: This
meta-analysis reported data on the prevalence of HO and severe HO after cervical
ADR, and provided information on its process of development. These should be
useful to enable surgeons and patients to gain a better understanding of HO after
cervical ADR.