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2010 ; 3
(3
): 273-275
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English Wikipedia
Simvastatin-induced myoglobinuric acute kidney injury following ciclosporin
treatment for alopecia universalis
#MMPMID28657046
Teutonico A
; Libutti P
; Lomonte C
; Basile C
NDT Plus
2010[Jun]; 3
(3
): 273-275
PMID28657046
show ga
Alopecia areata can affect the entire scalp (alopecia totalis) or cause loss of
all body hair (alopecia universalis). Ciclosporin (CsA) has been suggested for
its treatment, with controversial results. Concomitant use of statins and CsA may
increase the risk of rhabdomyolysis due to drug-drug interactions. Here we report
the case of a 45-year-old woman treated with CsA for alopecia universalis, who
presented a severe myoglobinuric acute kidney injury following the concomitant
use of simvastatin. Upon admission to our unit, she was oligo-anuric. Her serum
creatinine level was 13.8 mg/dl. CsA and simvastatin therapy were stopped, and
haemodialysis treatment was started (eight daily dialysis sessions) until
sufficient kidney function was regained. After 1 month, her serum creatinine
level was 3.5 mg/dl; after 2 months and onwards (follow-up of 4 months), her
serum creatinine level was 1.4 mg/dl and creatinine clearance was 43.2 ml/min. In
conclusion, physicians should be aware of the potential risks of the combined use
of CsA and statins. Patients should be advised to report any muscle symptoms when
they are on statins and CsA. The laboratory follow-up should include the
monitoring of serum creatinine and muscle enzyme levels, blood CsA levels and
liver function tests.