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2008 ; 1
(6
): 423-426
Nephropedia Template TP
gab.com Text
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English Wikipedia
Interleukin-6 receptor inhibition with tocilizumab in various renal involvements
associated with multicentric Castleman s disease: a report of three cases
#MMPMID28656995
Komaba H
; Nakazawa T
; Yamaguchi Y
; Kumagai S
; Fukagawa M
NDT Plus
2008[Dec]; 1
(6
): 423-426
PMID28656995
show ga
Multicentric Castleman's disease (MCD) is an inflammatory lymphoproliferative
disorder characterized by polyclonal hypergammopathy and dysregulated
overproduction of interleukin-6 (IL-6). A variety of renal involvements
infrequently arise in patients with MCD. However, there is no established
treatment for MCD and its associated renal involvements. We present the effects
of an anti-IL-6 receptor monoclonal antibody, tocilizumab, on three patients with
MCD associated with various renal manifestations. In all three patients,
tocilizumab treatment was very effective in reducing proteinuria and stabilizing
renal function, as well as improving other clinical symptoms. These findings
indicate the pathological significance of IL-6 in renal involvements associated
with MCD, and the potential use of tocilizumab in its treatment.