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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Chem+Biol 2016 ; 11 (3): 669-80 Nephropedia Template TP
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Therapeutics targeting protein acetylation perturb latency of human viruses #MMPMID26845514
Conrad RJ; Ott M
ACS Chem Biol 2016[Mar]; 11 (3): 669-80 PMID26845514show ga
Persistent viral infections are widespread and represent significant public health burdens. Some viruses endure in a latent state by co-opting the host epigenetic machinery to manipulate viral gene expression. Small molecules targeting epigenetic pathways are now in the clinic for certain cancers and are considered as potential treatment strategies to reverse latency in HIV-infected individuals. In this review, we discuss how drugs interfering with one epigenetic pathway, protein acetylation, perturb latency of three families of pathogenic human viruses?retroviruses, herpesviruses, and papillomaviruses.