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10.1016/j.tem.2017.03.003 http://scihub22266oqcxt.onion/10.1016/j.tem.2017.03.003 C5477655!5477655!28416361     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Endocrinol+Metab 2017 ; 28 (7): 497-505 Nephropedia Template TP {{tp|p=28416361|t=2017. Unraveling the Regulation of Hepatic Metabolism by Insulin |pdf=|usr=}}{{28416361}} gab.com Text Unraveling the Regulation of Hepatic Metabolism by Insulin JO: Trends Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=28416361 #FOAvip During insulin-resistant states such as type 2 diabetes mellitus (T2DM), insulin fails to suppress hepatic glucose production yet promotes lipid synthesis leading to hyperglycemia and hypertriglyceridemia. Defining the downstream signaling pathways underlying the control of hepatic metabolism by insulin is necessary for understanding both normal physiology and the pathogenesis of metabolic disease. Here, we summarize recent literature highlighting the importance of both hepatic and extra-hepatic mechanisms in insulin?s regulation of liver glucose and lipid metabolism. We posit that a failure of insulin to inappropriately regulate liver metabolism during T2DM is not exclusively from an inherent defect in canonical liver insulin signaling but, rather, due to a combination of hyperinsulinemia, altered substrate supply, and the input of several extra-hepatic signals. Twit Text FOAVip Unraveling the Regulation of Hepatic Metabolism by Insulin ????Trends Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=28416361 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28416361 #FOAvip English Wikipedia <ref>{{Cite pmid|28416361}}</ref> Unraveling the Regulation of Hepatic Metabolism by Insulin #MMPMID28416361 Titchenell PM; Lazar MA; Birnbaum MJ Trends Endocrinol Metab 2017[Jul]; 28 (7): 497-505 PMID28416361show ga During insulin-resistant states such as type 2 diabetes mellitus (T2DM), insulin fails to suppress hepatic glucose production yet promotes lipid synthesis leading to hyperglycemia and hypertriglyceridemia. Defining the downstream signaling pathways underlying the control of hepatic metabolism by insulin is necessary for understanding both normal physiology and the pathogenesis of metabolic disease. Here, we summarize recent literature highlighting the importance of both hepatic and extra-hepatic mechanisms in insulin?s regulation of liver glucose and lipid metabolism. We posit that a failure of insulin to inappropriately regulate liver metabolism during T2DM is not exclusively from an inherent defect in canonical liver insulin signaling but, rather, due to a combination of hyperinsulinemia, altered substrate supply, and the input of several extra-hepatic signals. äUnraveling the Regulation of Hepatic Metabolism by Insulin (epmc).pdf DeepDyve Pubget Overpricing