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10.3324/haematol.2016.160432 http://scihub22266oqcxt.onion/10.3324/haematol.2016.160432 C5477599!5477599!28280078     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Haematologica 2017 ; 102 (5): 809-17 Nephropedia Template TP {{tp|p=28280078|t=2017. Pathophysiological consequences and benefits of HFE mutations: 20 years of research |pdf=|usr=}}{{28280078}} gab.com Text Pathophysiological consequences and benefits of HFE mutations: 20 years of research JO: Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=28280078 #FOAvip Mutations in the HFE (hemochromatosis) gene cause hereditary hemochromatosis, an iron overload disorder that is hallmarked by excessive accumulation of iron in parenchymal organs. The HFE mutation p.Cys282Tyr is pathologically most relevant and occurs in the Caucasian population with a carrier frequency of up to 1 in 8 in specific European regions. Despite this high prevalence, the mutation causes a clinically relevant phenotype only in a minority of cases. In this review, we summarize historical facts and recent research findings about hereditary hemochromatosis, and outline the pathological consequences of the associated gene defects. In addition, we discuss potential advantages of HFE mutations in asymptomatic carriers. Twit Text FOAVip Pathophysiological consequences and benefits of HFE mutations: 20 years of research ????Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=28280078 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28280078 #FOAvip English Wikipedia <ref>{{Cite pmid|28280078}}</ref> Pathophysiological consequences and benefits of HFE mutations: 20 years of research #MMPMID28280078 Hollerer I; Bachmann A; Muckenthaler MU Haematologica 2017[May]; 102 (5): 809-17 PMID28280078show ga Mutations in the HFE (hemochromatosis) gene cause hereditary hemochromatosis, an iron overload disorder that is hallmarked by excessive accumulation of iron in parenchymal organs. The HFE mutation p.Cys282Tyr is pathologically most relevant and occurs in the Caucasian population with a carrier frequency of up to 1 in 8 in specific European regions. Despite this high prevalence, the mutation causes a clinically relevant phenotype only in a minority of cases. In this review, we summarize historical facts and recent research findings about hereditary hemochromatosis, and outline the pathological consequences of the associated gene defects. In addition, we discuss potential advantages of HFE mutations in asymptomatic carriers. äPathophysiological consequences and benefits of HFE mutations: 20 year(epmc).pdf DeepDyve Pubget Overpricing