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10.1038/ncomms10578 http://scihub22266oqcxt.onion/10.1038/ncomms10578 C5477503!5477503!26902267     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26902267|t=2016. An interactive web-based application for Comprehensive Analysis of RNAi-screen Data |pdf=|usr=}}{{26902267}} gab.com Text An interactive web-based application for Comprehensive Analysis of RNAi-screen Data JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26902267 #FOAvip RNAi screens are widely used in functional genomics. Although the screen data can be susceptible to a number of experimental biases, many of these can be corrected by computational analysis. For this purpose, here we have developed a web-based platform for integrated analysis and visualization of RNAi screen data named CARD (for Comprehensive Analysis of RNAi Data; available at https://card.niaid.nih.gov). CARD allows the user to seamlessly carry out sequential steps in a rigorous data analysis workflow, including normalization, off-target analysis, integration of gene expression data, optimal thresholds for hit selection and network/pathway analysis. To evaluate the utility of CARD, we describe analysis of three genome-scale siRNA screens and demonstrate: (i) a significant increase both in selection of subsequently validated hits and in rejection of false positives, (ii) an increased overlap of hits from independent screens of the same biology and (iii) insight to microRNA (miRNA) activity based on siRNA seed enrichment. Twit Text FOAVip An interactive web-based application for Comprehensive Analysis of RNAi-screen Data ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26902267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26902267 #FOAvip English Wikipedia <ref>{{Cite pmid|26902267}}</ref> An interactive web-based application for Comprehensive Analysis of RNAi-screen Data #MMPMID26902267 Dutta B; Azhir A; Merino LH; Guo Y; Revanur S; Madhamshettiwar PB; Germain RN; Smith JA; Simpson KJ; Martin SE; Beuhler E; Fraser IDC Nat Commun 2016[]; 7 (ä): ä PMID26902267show ga RNAi screens are widely used in functional genomics. Although the screen data can be susceptible to a number of experimental biases, many of these can be corrected by computational analysis. For this purpose, here we have developed a web-based platform for integrated analysis and visualization of RNAi screen data named CARD (for Comprehensive Analysis of RNAi Data; available at https://card.niaid.nih.gov). CARD allows the user to seamlessly carry out sequential steps in a rigorous data analysis workflow, including normalization, off-target analysis, integration of gene expression data, optimal thresholds for hit selection and network/pathway analysis. To evaluate the utility of CARD, we describe analysis of three genome-scale siRNA screens and demonstrate: (i) a significant increase both in selection of subsequently validated hits and in rejection of false positives, (ii) an increased overlap of hits from independent screens of the same biology and (iii) insight to microRNA (miRNA) activity based on siRNA seed enrichment. äAn interactive web-based application for Comprehensive Analysis of RNA(epmc).pdf DeepDyve Pubget Overpricing