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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BMC+Pulm+Med 2017 ; 17 (ä): ä Nephropedia Template TP
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Three-dimensional substructure measurements for the differential diagnosis of ground glass nodules #MMPMID28629453
Peng M; Yu G; Zhang C; Li C; Wang J
BMC Pulm Med 2017[]; 17 (ä): ä PMID28629453show ga
Background: We analyzed the differences between maximum and peak computed tomography (CT) numbers (M-P), respectively representing the densities of the solid center and the main periphery of ground-glass nodules (GGNs), and the average change in M-P velocity (V(M-P)) during follow-up to differentiate between pre-invasive (PIA) and invasive adenocarcinoma (IAC). Methods: Data of 102 patients were retrospectively collected and analyzed in our study including 43 PIAs and 59 IACs. Diameters, total volumes, and the maximum and peak CT numbers in CT number histograms were measured and followed for at least 3 months. This study was registered retrospectively. Results: The M-P values for IACs were higher than those for PIAs (p?=?0.001), with an area under the curve (AUC) of 0.810 and a threshold of 489.5 Hounsfield units (HU) in ROC analysis. The V(M-P) values for IACs were smaller than those for PIAs (p?=?0.04), with an AUC of 0.805 and a threshold of 11.01 HU/day. Conclusions: M-P and V(M-P) values may help distinguish IACs from PIAs by representing the changes in the sub-structural densities of GGNs during follow-up.