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2017 ; 17
(1
): 197
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Incidence, management and outcome of women requiring massive transfusion after
childbirth in the Netherlands: secondary analysis of a nationwide cohort study
between 2004 and 2006
#MMPMID28629440
Ramler PI
; van den Akker T
; Henriquez DDCA
; Zwart JJ
; van Roosmalen J
BMC Pregnancy Childbirth
2017[Jun]; 17
(1
): 197
PMID28629440
show ga
BACKGROUND: Postpartum hemorrhage remains the leading cause of maternal morbidity
and mortality worldwide. Few population-based studies have examined the
epidemiology of massive transfusion for postpartum hemorrhage. The aim of this
study was to determine the incidence, management, and outcomes of women with
postpartum hemorrhage who required massive transfusion in the Netherlands between
2004 and 2006. METHODS: Data for all women from a gestational age of 20 weeks
onwards who had postpartum hemorrhage requiring eight or more red blood cell
concentrates were obtained from a nationwide population-based cohort study
including all 98 hospitals with a maternity unit in the Netherlands. RESULTS:
Three hundred twenty-seven women who had postpartum hemorrhage requiring massive
transfusion were identified (massive transfusion rate 91 per 100,000 deliveries
(95% confidence interval: 81-101)). The median blood loss was 4500 mL
(interquartile range 3250-6000 mL) and the median number of red blood cell
concentrates transfused was 11 units (interquartile range 9-16 units). Among
women receiving massive transfusion, the most common cause of hemorrhage was
uterine atony. Eighty-three women (25%) underwent hysterectomy, 227 (69%) were
admitted to an intensive care unit, and three women died (case fatality rate
0,9%). CONCLUSION: The number of women in the Netherlands who had postpartum
hemorrhage treated with massive transfusion was relatively high compared to other
comparable settings. Evidence-based uniform management guidelines are necessary.
|Adult
[MESH]
|Blood Transfusion/*statistics & numerical data
[MESH]