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10.1146/annurev-pharmtox-070115-095427 http://scihub22266oqcxt.onion/10.1146/annurev-pharmtox-070115-095427 C5477061!5477061!26566153     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Pharmacol+Toxicol 2016 ; 56 (ä): 627-53 Nephropedia Template TP {{tp|p=26566153|t=2016. EGFR transactivation: mechanisms, pathophysiology and potential therapies in cardiovascular system |pdf=|usr=}}{{26566153}} gab.com Text EGFR transactivation: mechanisms, pathophysiology and potential therapies in cardiovascular system JO: Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=26566153 #FOAvip Accumulating studies suggest that the epidermal growth factor receptor (EGFR) activation is associated with the physiology and pathophysiology of the cardiovascular system, and inhibition of EGFR activity is emerging as a potential therapeutic strategy to treat diseases, including hypertension, cardiac hypertrophy, renal fibrosis and abdominal aortic aneurysm. The capacity of G protein-coupled receptor (GPCR) agonists, such as angiotensin II (AngII), to promote EGFR signaling is well described ? a process termed EGFR ?transactivation? ? yet delineating the molecular processes and functional relevance of this crosstalk has been challenging. Moreover, these critical findings are dispersed among many different fields. The aim of our review is to highlight the recent advancement of the signaling cascades and downstream consequences of EGFR transactivation within the cardiovascular renal system in vitro and in vivo. We will also focus on linking EGFR transactivation to animal models of the disease as well as the potential therapeutic applications. Twit Text FOAVip EGFR transactivation: mechanisms, pathophysiology and potential therapies in cardiovascular system ????Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=26566153 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26566153 #FOAvip English Wikipedia <ref>{{Cite pmid|26566153}}</ref> EGFR transactivation: mechanisms, pathophysiology and potential therapies in cardiovascular system #MMPMID26566153 Forrester SJ; Kawai T; Elliott KJ; O?Brien S; Thomas W; Harris RC; Eguchi S Annu Rev Pharmacol Toxicol 2016[]; 56 (ä): 627-53 PMID26566153show ga Accumulating studies suggest that the epidermal growth factor receptor (EGFR) activation is associated with the physiology and pathophysiology of the cardiovascular system, and inhibition of EGFR activity is emerging as a potential therapeutic strategy to treat diseases, including hypertension, cardiac hypertrophy, renal fibrosis and abdominal aortic aneurysm. The capacity of G protein-coupled receptor (GPCR) agonists, such as angiotensin II (AngII), to promote EGFR signaling is well described ? a process termed EGFR ?transactivation? ? yet delineating the molecular processes and functional relevance of this crosstalk has been challenging. Moreover, these critical findings are dispersed among many different fields. The aim of our review is to highlight the recent advancement of the signaling cascades and downstream consequences of EGFR transactivation within the cardiovascular renal system in vitro and in vivo. We will also focus on linking EGFR transactivation to animal models of the disease as well as the potential therapeutic applications. äEGFR transactivation: mechanisms, pathophysiology and potential therap(epmc).pdf DeepDyve Pubget Overpricing