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10.14283/jfa.2014.18 http://scihub22266oqcxt.onion/10.14283/jfa.2014.18 C5476958!5476958!27050062     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Frailty+Aging 2014 ; 3 (3): 158-65 Nephropedia Template TP {{tp|p=27050062|t=2014. Frailty and Pre-Frailty in a Contemporary Cohort of HIV-Infected Adults |pdf=|usr=}}{{27050062}} gab.com Text Frailty and Pre-Frailty in a Contemporary Cohort of HIV-Infected Adults JO: J Frailty Aging http://www.kidney.de/pget.php?&tw=1&pmid=27050062 #FOAvip Objectives: To determine the prevalence of pre-frailty among HIV-infected persons and associations with pre-frailty and frailty in this population. Design, Setting and Participants: From a contemporary, prospective observational cohort of HIV-infected persons (SUN Study), we determined, using a cross-sectional analytic study design, the proportions of non-frail, pre-frail, and frail persons by the respective presence of 0, 1-2, and ? 3 of 5 established frailty criteria: unintentional weight loss, exhaustion, physical-inactivity, weak-grip and slow-walk. We evaluated associations with pre-frailty/frailty using multivariate analysis. Results: Of 322 participants assessed (79% men, 58% white non-Hispanic, median age 47 years, 95% on combination antiretroviral therapy [cART], median CD4 + cell count 641 cells/mm3 and 93% HIV RNA < 400 copies/mL), 57% were non-frail, 38% pre-frail, and 5% frail. Age increased from non-frailty through frailty. Notably, however, half of pre-frail and frail participants were < 50 years, and of those, 42% and 100%, respectively, were long-term unemployed (versus 16% of non-frail counterparts). In multivariate analysis, pre-frail/frail participants were more likely to have Hepatitis C seropositivity (adjusted odds ratio [aOR] 3.24, 95% CI: 1.35-7.78), a history of AIDS-defining-illness (aOR 3.51, 95% CI: 1.82-6.76), greater depressive symptoms (aOR 1.16, 95% CI:1.09-1.23), higher D-dimer levels (aOR 2.94, 95% CI:1.10-7.87), and were less likely to be white non-Hispanic (aOR 0.35, 95% CI: 0.20-0.61). Conclusions: Pre-frailty and frailty are prevalent in the cART era and are associated with unemployment even among persons < 50 years. Pre-frailty appears to be an intermediate state in the spectrum from non-frailty through frailty and our characterization of pre-frailty/frailty suggests complex multifactorial associations. Twit Text FOAVip Frailty and Pre-Frailty in a Contemporary Cohort of HIV-Infected Adults ????J Frailty Aging http://www.kidney.de/pget.php?&tw=1&pmid=27050062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27050062 #FOAvip English Wikipedia <ref>{{Cite pmid|27050062}}</ref> Frailty and Pre-Frailty in a Contemporary Cohort of HIV-Infected Adults #MMPMID27050062 Önen N; Patel P; Baker J; Conley L; Brooks J; Bush T; Henry K; Hammer J; Kojic E; Overton E J Frailty Aging 2014[]; 3 (3): 158-65 PMID27050062show ga Objectives: To determine the prevalence of pre-frailty among HIV-infected persons and associations with pre-frailty and frailty in this population. Design, Setting and Participants: From a contemporary, prospective observational cohort of HIV-infected persons (SUN Study), we determined, using a cross-sectional analytic study design, the proportions of non-frail, pre-frail, and frail persons by the respective presence of 0, 1-2, and ? 3 of 5 established frailty criteria: unintentional weight loss, exhaustion, physical-inactivity, weak-grip and slow-walk. We evaluated associations with pre-frailty/frailty using multivariate analysis. Results: Of 322 participants assessed (79% men, 58% white non-Hispanic, median age 47 years, 95% on combination antiretroviral therapy [cART], median CD4 + cell count 641 cells/mm3 and 93% HIV RNA < 400 copies/mL), 57% were non-frail, 38% pre-frail, and 5% frail. Age increased from non-frailty through frailty. Notably, however, half of pre-frail and frail participants were < 50 years, and of those, 42% and 100%, respectively, were long-term unemployed (versus 16% of non-frail counterparts). In multivariate analysis, pre-frail/frail participants were more likely to have Hepatitis C seropositivity (adjusted odds ratio [aOR] 3.24, 95% CI: 1.35-7.78), a history of AIDS-defining-illness (aOR 3.51, 95% CI: 1.82-6.76), greater depressive symptoms (aOR 1.16, 95% CI:1.09-1.23), higher D-dimer levels (aOR 2.94, 95% CI:1.10-7.87), and were less likely to be white non-Hispanic (aOR 0.35, 95% CI: 0.20-0.61). Conclusions: Pre-frailty and frailty are prevalent in the cART era and are associated with unemployment even among persons < 50 years. Pre-frailty appears to be an intermediate state in the spectrum from non-frailty through frailty and our characterization of pre-frailty/frailty suggests complex multifactorial associations. äFrailty and Pre-Frailty in a Contemporary Cohort of HIV-Infected Adult(epmc).pdf DeepDyve Pubget Overpricing