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2017 ; 2017
(ä): 4580967
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English Wikipedia
Improvement of Arterial Wall Lesions in Parallel with Decrease of Plasma
Pentraxin-3 Levels in a Patient with Refractory Takayasu Arteritis after
Treatment with Tocilizumab
#MMPMID28676840
Iwagaitsu S
; Naniwa T
Case Rep Rheumatol
2017[]; 2017
(ä): 4580967
PMID28676840
show ga
A 19-year-old Japanese woman with active Takayasu arteritis despite multiple
conventional immunosuppressive therapies with glucocorticoids in combination with
intravenous cyclophosphamide, azathioprine, or infliximab with methotrexate and
tacrolimus was successfully treated by switching from infliximab to intravenous
tocilizumab. Worsening of claudication of the legs and elevated acute phase
reactants, including plasma pentraxin-3 levels, were observed during combination
therapy with infliximab. Computed tomography demonstrated increased wall
thickening with contrast enhancement in the preexisting lesion of the descending
aorta and the femoral arteries. After switching from infliximab to tocilizumab,
plasma pentraxin-3 levels gradually decreased to the normal range in parallel
with the improvement of claudication. Follow-up computed tomographic scans
confirmed the marked improvement of these arterial lesions. Moreover, plasma
pentraxin-3 level was increased in response to the worsening of claudication that
occurred just after switching to a subcutaneous tocilizumab injection.
Measurements of plasma pentraxin-3 might be useful for evaluation of the vascular
wall inflammation and therapeutic efficacy even during biologic therapy targeting
tumor necrosis factor ? and interleukin-6.