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2017 ; 10
(ä): 2923-2930
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Vasculogenic mimicry is associated with increased tumor-infiltrating neutrophil
and poor outcome in esophageal squamous cell carcinoma
#MMPMID28652774
Zhang J
; Zhang G
; Hu P
; Deng G
; Liu Q
; Qiao L
; Luo H
; Zhang J
Onco Targets Ther
2017[]; 10
(ä): 2923-2930
PMID28652774
show ga
PURPOSE: Vasculogenic mimicry (VM) is known to be a mechanism to nourish the
tumor, but little is known about its prognostic significance in esophageal
squamous cell carcinoma (ESCC). We characterized the predictive relevance of VM
expression and tumor-infiltrating neutrophil (TIN) density in patients with
resectable ESCC. METHODS: We retrospectively collected clinicopathologic
characteristics of 117 esophageal cancer (EC) patients undergoing complete
resection and without preoperative therapy. Immunohistochemistry was used to
detect the expression of E-cadherin and CD66b. CD34/periodic acid-schiff (PAS)
double staining was used to detect the expression of VM. RESULTS: VM expression
was observed in 56 (47.9%) patients. VM was negatively correlated with E-cadherin
(correlation coefficient =-0.364, P<0.001) and was positively correlated with
infiltration of CD66b neutrophil (correlation coefficient =0.421, P<0.001). VM
and CD66b(+) neutrophil infiltration are important markers for poor overall
survival and disease-free survival. Multivariate analysis showed that VM,
CD66b(+) neutrophil infiltration, pathologic tumor node metastasis (TNM) (pTNM)
stage, and tumor differentiation are significant independent prognostic
predictors in ECs (P=0.001, 0.025, 0.001, 0.011, respectively). VM expression is
identified in ~47.9% of ESCC, and it is associated with poor outcome and
increased TIN. CONCLUSION: TIN is an important factor for VM formation.
Therefore, studies of invasive ability of EC in patients with VM could supply
significant information for therapeutic strategy.