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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sci+Rep
2017 ; 7
(1
): 3802
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Hyperuricemia and overexcretion of uric acid increase the risk of simple renal
cysts in type 2 diabetes
#MMPMID28630500
Han Y
; Zhang M
; Lu J
; Zhang L
; Han J
; Zhao F
; Chen H
; Bao Y
; Jia W
Sci Rep
2017[Jun]; 7
(1
): 3802
PMID28630500
show ga
Previous studies have discussed the relationship between simple renal cysts (SRC)
and serum uric acid level in healthy individuals. We performed a cross-sectional
study to evaluate the association between serum uric acid level and fractional
excretion of uric acid (FEUA) and simple renal cysts in males and postmenopausal
females with type 2 diabetes. The overall prevalence of SRC was 18.1% in our
population. SRC prevalence was significantly higher in hyperuricemic than
normouricemic subjects (27.3% vs. 16.8%, P?0.001). Subjects who overexcreted
uric acid had a higher prevalence of SRC than underexcretors (total population:
21.6% vs. 16.3%; normouricemic subjects: 19.8% vs. 13.7%; hyperuricemic subjects:
50.0% vs. 22.7%, all P-values?0.05). Hyperuricemia (odds ratio [OR] 1.824, 95%
confidence interval [CI] 1.332-2.498, P?0.001); FEUA (OR 1.046, 95% CI
1.002-1.091, P?0.05); male gender (OR 1.922, 95% CI 1.489-2.480, P?0.001);
age (OR 1.049, 95% CI 1.035-1.064, P?0.001); and albuminuria (OR 1.492, 95% CI
1.176-1.892, P?0.01) were independent risk factors for SRC development. These
findings suggested that hyperuricemia and high level of FEUA were both
independent risk factors for SRC development in males and postmenopausal females
with type 2 diabetes. Half of overproduction hyperuricemic patients had SRC.
|Aged
[MESH]
|Cysts/pathology/*urine
[MESH]
|Diabetes Mellitus, Type 2/epidemiology/pathology/*urine
[MESH]