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Disentangling a Bad Reputation: Changing Perceptions of Amyloids #MMPMID28359692
Wang M; Audas TE; Lee S
Trends Cell Biol 2017[Jul]; 27 (7): 465-7 PMID28359692show ga
Historically, amyloids were perceived as toxic/irreversible protein aggregates associated with neurodegenerative disorders, including Alzheimer?s and Parkinson?s diseases. Recent papers are challenging this perception by uncovering widespread cellular roles for physiological amyloidogenesis. These findings suggest that the amyloid-fold should be considered, alongside native-fold and unfolded, as physiological and reversible protein organization.