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10.1016/j.jhep.2017.02.025 http://scihub22266oqcxt.onion/10.1016/j.jhep.2017.02.025 C5476485!5476485!28267623     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hepatol 2017 ; 67 (1): 100-9 Nephropedia Template TP {{tp|p=28267623|t=2017. Thymic NF-?B-inducing Kinase (NIK) Regulates CD4+ T Cell-elicited Liver Injury and Fibrosis in Mice |pdf=|usr=}}{{28267623}} gab.com Text Thymic NF- B-inducing Kinase (NIK) Regulates CD4+ T Cell-elicited Liver Injury and Fibrosis in Mice JO: J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=28267623 #FOAvip Background & Aims: The liver is an immunologically-privileged organ. Breakdown of liver immune privilege has been reported in chronic liver disease; however, the role of adaptive immunity in liver injury is poorly defined. NIK is known to regulate immune tissue development, but its role in maintaining liver homeostasis remains unknown. This study aimed to assess the role of NIK, particularly thymic NIK, in regulating liver adaptive immunity. Methods: NIK was deleted systemically or conditionally using the cre/loxp system. CD4+ or CD8+ T cells were depleted using anti-CD4 or anti-CD8 antibody. Donor bone marrows or thymi were transferred into recipient mice. Immune cells were assessed by immunohistochemistry and flow cytometry. Results: Global, but not liver-specific or hematopoietic lineage cell-specific, deletion of NIK induced fatal liver injury, inflammation, and fibrosis. Likewise, adoptive transfer of NIK-null, but not wild type, thymi into immune-deficient mice induced liver inflammation, injury, and fibrosis in recipients. Liver inflammation was characterized by a massive expansion of T cells, particularly the CD4+ T cell subpopulation. Depletion of CD4+, but not CD8+, T cells fully protected against liver injury, inflammation, and fibrosis in NIK-null mice. NIK deficiency also resulted in inflammation in the lung, kidney, and pancreas, but to a lesser degree relative to the liver. Conclusions: Thymic NIK suppresses development of autoreactive T cells against liver antigens, and NIK deficiency in the thymus results in CD4+ T cell-orchestrated autoimmune hepatitis and liver fibrosis. Thus, thymic NIK is indispensable for the maintenance of liver immune privilege and liver homeostasis. Twit Text FOAVip Thymic NF- B-inducing Kinase (NIK) Regulates CD4+ T Cell-elicited Liver Injury and Fibrosis in Mice ????J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=28267623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28267623 #FOAvip English Wikipedia <ref>{{Cite pmid|28267623}}</ref> Thymic NF-?B-inducing Kinase (NIK) Regulates CD4+ T Cell-elicited Liver Injury and Fibrosis in Mice #MMPMID28267623 Shen H; Sheng L; Xiong Y; Kim YH; Jiang L; Chen Z; Liu Y; Pyaram K; Chang CH; Rui L J Hepatol 2017[Jul]; 67 (1): 100-9 PMID28267623show ga Background & Aims: The liver is an immunologically-privileged organ. Breakdown of liver immune privilege has been reported in chronic liver disease; however, the role of adaptive immunity in liver injury is poorly defined. NIK is known to regulate immune tissue development, but its role in maintaining liver homeostasis remains unknown. This study aimed to assess the role of NIK, particularly thymic NIK, in regulating liver adaptive immunity. Methods: NIK was deleted systemically or conditionally using the cre/loxp system. CD4+ or CD8+ T cells were depleted using anti-CD4 or anti-CD8 antibody. Donor bone marrows or thymi were transferred into recipient mice. Immune cells were assessed by immunohistochemistry and flow cytometry. Results: Global, but not liver-specific or hematopoietic lineage cell-specific, deletion of NIK induced fatal liver injury, inflammation, and fibrosis. Likewise, adoptive transfer of NIK-null, but not wild type, thymi into immune-deficient mice induced liver inflammation, injury, and fibrosis in recipients. Liver inflammation was characterized by a massive expansion of T cells, particularly the CD4+ T cell subpopulation. Depletion of CD4+, but not CD8+, T cells fully protected against liver injury, inflammation, and fibrosis in NIK-null mice. NIK deficiency also resulted in inflammation in the lung, kidney, and pancreas, but to a lesser degree relative to the liver. Conclusions: Thymic NIK suppresses development of autoreactive T cells against liver antigens, and NIK deficiency in the thymus results in CD4+ T cell-orchestrated autoimmune hepatitis and liver fibrosis. Thus, thymic NIK is indispensable for the maintenance of liver immune privilege and liver homeostasis. äThymic NF-?B-inducing Kinase (NIK) Regulates CD4+ T Cell-elicited Live(epmc).pdf DeepDyve Pubget Overpricing