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10.1097/WAD.0000000000000202 http://scihub22266oqcxt.onion/10.1097/WAD.0000000000000202 C5476214!5476214!28538088     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Alzheimer+Dis+Assoc+Disord 2017 ; 31 (2): 107-13 Nephropedia Template TP {{tp|p=28538088|t=2017. Effects of the Insulin Sensitizer Metformin in Alzheimer?s Disease: Pilot Data from a Randomized Placebo-Controlled Crossover Study |pdf=|usr=}}{{28538088}} gab.com Text Effects of the Insulin Sensitizer Metformin in Alzheimer s Disease: Pilot Data from a Randomized Placebo-Controlled Crossover Study JO: Alzheimer Dis Assoc Disord http://www.kidney.de/pget.php?&tw=1&pmid=28538088 #FOAvip Epidemiological studies have identified a robust association between Type II Diabetes Mellitus (T2DM) and Alzheimer?s Disease (AD), and neurobiological studies have suggested the presence of central nervous system (CNS) insulin resistance in individuals with AD. Given this association, we hypothesized that the CNS-penetrant insulin-sensitizing medication metformin would be beneficial as a disease modifying and/or symptomatic therapy for AD, and conducted a placebo-controlled crossover study of its effects on cerebrospinal fluid (CSF), neuroimaging, and cognitive biomarkers. Twenty non-diabetic subjects with mild cognitive impairment or mild dementia due to AD were randomized to receive metformin then placebo for 8 weeks each or vice versa. CSF and neuroimaging (Arterial Spin Label MRI) data were collected for biomarker analyses, and cognitive testing was performed. Metformin was found to be safe, well-tolerated, and measureable in CSF at an average steady-state concentration of 95.6 ng/ml. Metformin was associated with improved executive functioning, and trends suggested improvement in learning/memory and attention. No significant changes in cerebral blood flow (CBF) were observed, though post-hoc completer analyses suggested an increase in orbitofrontal CBF with metformin exposure. Further study of these findings is warranted. Twit Text FOAVip Effects of the Insulin Sensitizer Metformin in Alzheimer s Disease: Pilot Data from a Randomized Placebo-Controlled Crossover Study ????Alzheimer Dis Assoc Disord http://www.kidney.de/pget.php?&tw=1&pmid=28538088 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28538088 #FOAvip English Wikipedia <ref>{{Cite pmid|28538088}}</ref> Effects of the Insulin Sensitizer Metformin in Alzheimer?s Disease: Pilot Data from a Randomized Placebo-Controlled Crossover Study #MMPMID28538088 Koenig AM; Mechanic-Hamilton D; Xie SX; Combs MF; Cappola AR; Xie L; Detre JA; Wolk DA; Arnold SE Alzheimer Dis Assoc Disord 2017[Apr]; 31 (2): 107-13 PMID28538088show ga Epidemiological studies have identified a robust association between Type II Diabetes Mellitus (T2DM) and Alzheimer?s Disease (AD), and neurobiological studies have suggested the presence of central nervous system (CNS) insulin resistance in individuals with AD. Given this association, we hypothesized that the CNS-penetrant insulin-sensitizing medication metformin would be beneficial as a disease modifying and/or symptomatic therapy for AD, and conducted a placebo-controlled crossover study of its effects on cerebrospinal fluid (CSF), neuroimaging, and cognitive biomarkers. Twenty non-diabetic subjects with mild cognitive impairment or mild dementia due to AD were randomized to receive metformin then placebo for 8 weeks each or vice versa. CSF and neuroimaging (Arterial Spin Label MRI) data were collected for biomarker analyses, and cognitive testing was performed. Metformin was found to be safe, well-tolerated, and measureable in CSF at an average steady-state concentration of 95.6 ng/ml. Metformin was associated with improved executive functioning, and trends suggested improvement in learning/memory and attention. No significant changes in cerebral blood flow (CBF) were observed, though post-hoc completer analyses suggested an increase in orbitofrontal CBF with metformin exposure. Further study of these findings is warranted. äEffects of the Insulin Sensitizer Metformin in Alzheimer?s Disease: Pi(epmc).pdf DeepDyve Pubget Overpricing