Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ebiom.2017.01.040 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2017.01.040 C5474518!5474518!28161398     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2017 ; 16 (ä): 238-50 Nephropedia Template TP {{tp|p=28161398|t=2017. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3? Signaling Pathway |pdf=|usr=}}{{28161398}} gab.com Text Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3 Signaling Pathway JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=28161398 #FOAvip While angiotensin II (ang II) has been implicated in the pathogenesis of cardiac cachexia (CC), the molecules that mediate ang II's wasting effect have not been identified. It is known TNF-? level is increased in patients with CC, and TNF-? release is triggered by ang II. We therefore hypothesized that ang II induced muscle wasting is mediated by TNF-?. Ang II infusion led to skeletal muscle wasting in wild type (WT) but not in TNF alpha type 1 receptor knockout (TNFR1KO) mice, suggesting that ang II induced muscle loss is mediated by TNF-? through its type 1 receptor. Microarray analysis identified cholesterol 25-hydroxylase (Ch25h) as the down stream target of TNF-?. Intraperitoneal injection of 25-hydroxycholesterol (25-OHC), the product of Ch25h, resulted in muscle loss in C57BL/6 mice, accompanied by increased expression of atrogin-1, MuRF1 and suppression of IGF-1/Akt signaling pathway. The identification of 25-OHC as an inducer of muscle wasting has implications for the development of specific treatment strategies in preventing muscle loss. Twit Text FOAVip Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3 Signaling Pathway ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=28161398 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28161398 #FOAvip English Wikipedia <ref>{{Cite pmid|28161398}}</ref> Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3? Signaling Pathway #MMPMID28161398 Shen C; Zhou J; Wang X; Yu XY; Liang C; Liu B; Pan X; Zhao Q; Song JL; Wang J; Bao M; Wu C; Li Y; Song YH EBioMedicine 2017[Feb]; 16 (ä): 238-50 PMID28161398show ga While angiotensin II (ang II) has been implicated in the pathogenesis of cardiac cachexia (CC), the molecules that mediate ang II's wasting effect have not been identified. It is known TNF-? level is increased in patients with CC, and TNF-? release is triggered by ang II. We therefore hypothesized that ang II induced muscle wasting is mediated by TNF-?. Ang II infusion led to skeletal muscle wasting in wild type (WT) but not in TNF alpha type 1 receptor knockout (TNFR1KO) mice, suggesting that ang II induced muscle loss is mediated by TNF-? through its type 1 receptor. Microarray analysis identified cholesterol 25-hydroxylase (Ch25h) as the down stream target of TNF-?. Intraperitoneal injection of 25-hydroxycholesterol (25-OHC), the product of Ch25h, resulted in muscle loss in C57BL/6 mice, accompanied by increased expression of atrogin-1, MuRF1 and suppression of IGF-1/Akt signaling pathway. The identification of 25-OHC as an inducer of muscle wasting has implications for the development of specific treatment strategies in preventing muscle loss. äAngiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholest(epmc).pdf DeepDyve Pubget Overpricing