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10.1016/j.ebiom.2017.01.038 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2017.01.038 C5474516!5474516!28161399     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2017 ; 16 (ä): 101-5 Nephropedia Template TP {{tp|p=28161399|t=2017. BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility |pdf=|usr=}}{{28161399}} gab.com Text BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=28161399 #FOAvip BRCA1-associated RING domain protein 1 (BARD1) is a tumor suppressor, which forms a heterodimer with BRCA1. Three BARD1 gene polymorphisms (rs7585356 G > A, rs6435862 T > G and rs3768716 A > G) were initially identified as high-risk neuroblastoma susceptibility loci by a previous GWAS. Because of the general tumor-suppressing function of BARD1, we hypothesized that these BARD1 gene polymorphisms might modify the susceptibility to nephroblastoma. We genotyped these polymorphisms in 145 cases and 531 controls using Taqman methods. Out of three polymorphisms, only the rs7585356 G > A polymorphism was significantly associated with increased susceptibility to nephroblastoma [AA vs. GG: adjusted odds ratio (OR) = 1.78, 95% confidence interval (CI) = 1.01?3.12]. Combined analysis of three polymorphisms indicated that subjects with 3 risk genotypes exhibited significantly elevated nephroblastoma risk, when compared with subjects with 0?2 risk genotypes (adjusted OR = 1.72, 95% CI = 1.02?2.89). Stratified analysis revealed that in term of clinical stage, rs7585356 AA carriers were associated with increased risk of developing clinical stage I + II nephroblastoma. The presence of three risk genotypes was significantly associated with nephroblastoma risk in females and clinical stage I + II nephroblastoma. Our results suggested that BARD1 rs7585356 G > A may be associated with nephroblastoma risk. Twit Text FOAVip BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=28161399 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28161399 #FOAvip English Wikipedia <ref>{{Cite pmid|28161399}}</ref> BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility #MMPMID28161399 Fu W; Zhu J; Xiong SW; Jia W; Zhao Z; Zhu SB; Hu JH; Wang FH; Xia H; He J; Liu GC EBioMedicine 2017[Feb]; 16 (ä): 101-5 PMID28161399show ga BRCA1-associated RING domain protein 1 (BARD1) is a tumor suppressor, which forms a heterodimer with BRCA1. Three BARD1 gene polymorphisms (rs7585356 G > A, rs6435862 T > G and rs3768716 A > G) were initially identified as high-risk neuroblastoma susceptibility loci by a previous GWAS. Because of the general tumor-suppressing function of BARD1, we hypothesized that these BARD1 gene polymorphisms might modify the susceptibility to nephroblastoma. We genotyped these polymorphisms in 145 cases and 531 controls using Taqman methods. Out of three polymorphisms, only the rs7585356 G > A polymorphism was significantly associated with increased susceptibility to nephroblastoma [AA vs. GG: adjusted odds ratio (OR) = 1.78, 95% confidence interval (CI) = 1.01?3.12]. Combined analysis of three polymorphisms indicated that subjects with 3 risk genotypes exhibited significantly elevated nephroblastoma risk, when compared with subjects with 0?2 risk genotypes (adjusted OR = 1.72, 95% CI = 1.02?2.89). Stratified analysis revealed that in term of clinical stage, rs7585356 AA carriers were associated with increased risk of developing clinical stage I + II nephroblastoma. The presence of three risk genotypes was significantly associated with nephroblastoma risk in females and clinical stage I + II nephroblastoma. Our results suggested that BARD1 rs7585356 G > A may be associated with nephroblastoma risk. äBARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility (epmc).pdf DeepDyve Pubget Overpricing