Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ebiom.2017.01.006 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2017.01.006 C5474437!5474437 !28111237     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28111237 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EBioMedicine 2017 ; 16 (ä): 204-211 Nephropedia Template TP {{tp|p=28111237 |t=2017. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance |pdf=|usr=}}{{28111237 }} gab.com Text Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=28111237 #FOAvip Increases in plasma LDL-cholesterol have unequivocally been established as a causal risk factor for atherosclerosis. Hence, strategies for lowering of LDL-cholesterol may have immediate therapeutic relevance. Here we study the role of human neutrophil peptide 1 (HNP1) in a mouse model of atherosclerosis and identify its potent atheroprotective effect both upon transgenic overexpression and therapeutic delivery. The effect was found to be due to a reduction of plasma LDL-cholesterol. Mechanistically, HNP1 binds to apolipoproteins enriched in LDL. This interaction facilitates clearance of LDL particles in the liver via LDL receptor. Thus, we here identify a non-redundant mechanism by which HNP1 allows for reduction of LDL-cholesterol, a process that may be therapeutically instructed to lower cardiovascular risk. Twit Text FOAVip Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=28111237 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28111237 #FOAvip English Wikipedia <ref>{{Cite pmid|28111237 }}</ref> Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance #MMPMID28111237 Paulin N ; Döring Y ; Kooijman S ; Blanchet X ; Viola JR ; de Jong R ; Mandl M ; Hendrikse J ; Schiener M ; von Hundelshausen P ; Vogt A ; Weber C ; Bdeir K ; Hofmann SM ; Rensen PCN ; Drechsler M ; Soehnlein O EBioMedicine 2017[Feb]; 16 (ä): 204-211 PMID28111237 show ga Increases in plasma LDL-cholesterol have unequivocally been established as a causal risk factor for atherosclerosis. Hence, strategies for lowering of LDL-cholesterol may have immediate therapeutic relevance. Here we study the role of human neutrophil peptide 1 (HNP1) in a mouse model of atherosclerosis and identify its potent atheroprotective effect both upon transgenic overexpression and therapeutic delivery. The effect was found to be due to a reduction of plasma LDL-cholesterol. Mechanistically, HNP1 binds to apolipoproteins enriched in LDL. This interaction facilitates clearance of LDL particles in the liver via LDL receptor. Thus, we here identify a non-redundant mechanism by which HNP1 allows for reduction of LDL-cholesterol, a process that may be therapeutically instructed to lower cardiovascular risk. |Animals [MESH] |Apolipoproteins/blood/metabolism [MESH] |Atherosclerosis/genetics/*metabolism/prevention & control [MESH] |Cholesterol, LDL/blood/metabolism [MESH] |Female [MESH] |Hep G2 Cells [MESH] |Humans [MESH] |Hypercholesterolemia/genetics/*metabolism/prevention & control [MESH] |Immunohistochemistry [MESH] |Lipoproteins, LDL/blood/*metabolism/pharmacokinetics [MESH] |Liver/drug effects/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Microscopy, Confocal [MESH] |Protein Binding [MESH] |RNA Interference [MESH] |Receptors, LDL/genetics/metabolism [MESH]Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atheros(epmc).pdf DeepDyve Pubget Overpricing