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10.1016/j.cell.2016.06.011 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.06.011 C5474394!5474394!27419872     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 166 (2): 451-67 Nephropedia Template TP {{tp|p=27419872|t=2016. Mapping the pairwise choices leading from pluripotency to human bone, heart and other mesoderm cell-types |pdf=|usr=}}{{27419872}} gab.com Text Mapping the pairwise choices leading from pluripotency to human bone, heart and other mesoderm cell-types JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27419872 #FOAvip Stem-cell differentiation to desired lineages requires navigating alternating developmental paths often leading to unwanted cell-types. Hence comprehensive developmental roadmaps are crucial to channel stem-cell differentiation towards desired fates. To this end, here we map bifurcating lineage choices leading from pluripotency to twelve human mesodermal lineages, including bone, muscle and heart. We defined the extrinsic signals controlling each binary lineage decision, enabling us to logically block differentiation towards unwanted fates and rapidly steer pluripotent stem cells towards 80?99% pure human mesodermal lineages at most branchpoints. This strategy enabled the generation of human bone and heart progenitors that could engraft in respective in vivo models. Mapping stepwise chromatin and single-cell gene expression changes in mesoderm development uncovered somite segmentation, a previously-unobservable human embryonic event transiently marked by HOPX expression. Collectively this roadmap enables navigation of mesodermal development to produce transplantable human tissue progenitors and uncover developmental processes. Twit Text FOAVip Mapping the pairwise choices leading from pluripotency to human bone, heart and other mesoderm cell-types ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27419872 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27419872 #FOAvip English Wikipedia <ref>{{Cite pmid|27419872}}</ref> Mapping the pairwise choices leading from pluripotency to human bone, heart and other mesoderm cell-types #MMPMID27419872 Loh KM; Chen A; Koh PW; Deng TZ; Sinha R; Tsai JM; Barkal AA; Shen KY; Jain R; Morganti RM; Ng SC; Fernhoff NB; George BM; Wernig G; Salomon RE; Chen Z; Vogel H; Epstein JA; Kundaje A; Talbot WS; Beachy PA; Ang LT; Weissman IL Cell 2016[Jul]; 166 (2): 451-67 PMID27419872show ga Stem-cell differentiation to desired lineages requires navigating alternating developmental paths often leading to unwanted cell-types. Hence comprehensive developmental roadmaps are crucial to channel stem-cell differentiation towards desired fates. To this end, here we map bifurcating lineage choices leading from pluripotency to twelve human mesodermal lineages, including bone, muscle and heart. We defined the extrinsic signals controlling each binary lineage decision, enabling us to logically block differentiation towards unwanted fates and rapidly steer pluripotent stem cells towards 80?99% pure human mesodermal lineages at most branchpoints. This strategy enabled the generation of human bone and heart progenitors that could engraft in respective in vivo models. Mapping stepwise chromatin and single-cell gene expression changes in mesoderm development uncovered somite segmentation, a previously-unobservable human embryonic event transiently marked by HOPX expression. Collectively this roadmap enables navigation of mesodermal development to produce transplantable human tissue progenitors and uncover developmental processes. äMapping the pairwise choices leading from pluripotency to human bone, (epmc).pdf DeepDyve Pubget Overpricing