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2017 ; 2017
(ä): 6917941
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English Wikipedia
Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on
Target Cell Metabolism, Homeostasis, and Response to Therapy
#MMPMID28659978
Vignais ML
; Caicedo A
; Brondello JM
; Jorgensen C
Stem Cells Int
2017[]; 2017
(ä): 6917941
PMID28659978
show ga
Intercellular communications play a major role in tissue homeostasis and
responses to external cues. Novel structures for this communication have recently
been described. These tunneling nanotubes (TNTs) consist of thin-extended
membrane protrusions that connect cells together. TNTs allow the cell-to-cell
transfer of various cellular components, including proteins, RNAs, viruses, and
organelles, such as mitochondria. Mesenchymal stem cells (MSCs) are both
naturally present and recruited to many different tissues where their interaction
with resident cells via secreted factors has been largely documented. Their
immunosuppressive and repairing capacities constitute the basis for many current
clinical trials. MSCs recruited to the tumor microenvironment also play an
important role in tumor progression and resistance to therapy. MSCs are now the
focus of intense scrutiny due to their capacity to form TNTs and transfer
mitochondria to target cells, either in normal physiological or in pathological
conditions, leading to changes in cell energy metabolism and functions, as
described in this review.