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10.1158/1541-7786.MCR-16-0344 http://scihub22266oqcxt.onion/10.1158/1541-7786.MCR-16-0344 C5473959!5473959!28031410     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cancer+Res 2017 ; 15 (3): 348-57 Nephropedia Template TP {{tp|p=28031410|t=2017. Nuclear Import of JAK1 is Mediated by a Classical NLS and is Required for Survival of Diffuse Large B-cell Lymphoma |pdf=|usr=}}{{28031410}} gab.com Text Nuclear Import of JAK1 is Mediated by a Classical NLS and is Required for Survival of Diffuse Large B-cell Lymphoma JO: Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28031410 #FOAvip Janus kinases (JAKs) are non-receptor tyrosine kinases that are generally found in association with cytokine receptors. In the canonical pathway, roles of JAKs have well been established in activating signal transducers and activators of transcription (STATs) in response to cytokine stimulation to modulate gene transcription. In contrast, a non-canonical role of JAK2 has recently been discovered in which JAK2 in the nucleus imparts the epigenetic regulation of gene transcription through phosphorylation of tyrosine 41 on the histone protein H3. Recent work further demonstrated that this non-canonical mechanism is conserved with JAK1, which is activated by the autocrine cytokines IL-6 and IL-10 in activated B-cell-like diffuse large B cell lymphoma (ABC DLBCL), a cancer type that is particularly difficult to treat and has poor prognosis. However, how JAK1 gains access to the nucleus to enable epigenetic regulation remains undefined. Here we investigated this question and revealed that JAK1 has a classical nuclear localization signal (cNLS) toward the N-terminal region, which can be recognized by multiple importin alpha isoforms. Moreover, the nuclear import of JAK1 is independent of its kinase activity but is required for the optimal expansion of ABC DLBCL cells in vitro. Implications: This study demonstrates that the nuclear import of JAK1 is essential for the optimal fitness of ABC DLBCL cells and targeting JAK1 nuclear localization is a potential therapeutic strategy for ABC DLBCL. Twit Text FOAVip Nuclear Import of JAK1 is Mediated by a Classical NLS and is Required for Survival of Diffuse Large B-cell Lymphoma ????Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28031410 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28031410 #FOAvip English Wikipedia <ref>{{Cite pmid|28031410}}</ref> Nuclear Import of JAK1 is Mediated by a Classical NLS and is Required for Survival of Diffuse Large B-cell Lymphoma #MMPMID28031410 Zhu F; Hwang B; Miyamoto S; Rui L Mol Cancer Res 2017[Mar]; 15 (3): 348-57 PMID28031410show ga Janus kinases (JAKs) are non-receptor tyrosine kinases that are generally found in association with cytokine receptors. In the canonical pathway, roles of JAKs have well been established in activating signal transducers and activators of transcription (STATs) in response to cytokine stimulation to modulate gene transcription. In contrast, a non-canonical role of JAK2 has recently been discovered in which JAK2 in the nucleus imparts the epigenetic regulation of gene transcription through phosphorylation of tyrosine 41 on the histone protein H3. Recent work further demonstrated that this non-canonical mechanism is conserved with JAK1, which is activated by the autocrine cytokines IL-6 and IL-10 in activated B-cell-like diffuse large B cell lymphoma (ABC DLBCL), a cancer type that is particularly difficult to treat and has poor prognosis. However, how JAK1 gains access to the nucleus to enable epigenetic regulation remains undefined. Here we investigated this question and revealed that JAK1 has a classical nuclear localization signal (cNLS) toward the N-terminal region, which can be recognized by multiple importin alpha isoforms. Moreover, the nuclear import of JAK1 is independent of its kinase activity but is required for the optimal expansion of ABC DLBCL cells in vitro. Implications: This study demonstrates that the nuclear import of JAK1 is essential for the optimal fitness of ABC DLBCL cells and targeting JAK1 nuclear localization is a potential therapeutic strategy for ABC DLBCL. äNuclear Import of JAK1 is Mediated by a Classical NLS and is Required (epmc).pdf DeepDyve Pubget Overpricing