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10.1038/s41598-017-03389-2 http://scihub22266oqcxt.onion/10.1038/s41598-017-03389-2 C5473841!5473841 !28623272     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28623272 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 3710 Nephropedia Template TP {{tp|p=28623272 |t=2017. Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells |pdf=|usr=}}{{28623272 }} gab.com Text Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28623272 #FOAvip Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic liver disease, but the exact mechanism of progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains unknown. Here, we investigated the role of exosomes in NAFLD progression. Exosomes were isolated from a human hepatoma cell line treated with palmitic acid (PA) and their miRNA profiles examined by microarray. The human hepatic stellate cell (HSC) line (LX-2) was then treated with exosome isolated from hepatocytes. Compared with controls, PA-treated hepatocytes displayed significantly increased CD36 and exosome production. The microarray analysis showed there to be distinctive miRNA expression patterns between exosomes from vehicle- and PA-treated hepatocytes. When LX-2 cells were cultured with exosomes from PA-treated hepatocytes, the expression of genes related to the development of fibrosis were significantly amplified compared to those treated with exosomes from vehicle-treated hepatocytes. In conclusion, PA treatment enhanced the production of exosomes in these hepatocytes and changed their exosomal miRNA profile. Moreover, exosomes derived from PA-treated hepatocytes caused an increase in the expression levels of fibrotic genes in HSCs. Therefore, exosomes may have important roles in the crosstalk between hepatocytes and HSCs in the progression from simple steatosis to NASH. Twit Text FOAVip Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28623272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28623272 #FOAvip English Wikipedia <ref>{{Cite pmid|28623272 }}</ref> Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells #MMPMID28623272 Lee YS ; Kim SY ; Ko E ; Lee JH ; Yi HS ; Yoo YJ ; Je J ; Suh SJ ; Jung YK ; Kim JH ; Seo YS ; Yim HJ ; Jeong WI ; Yeon JE ; Um SH ; Byun KS Sci Rep 2017[Jun]; 7 (1 ): 3710 PMID28623272 show ga Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic liver disease, but the exact mechanism of progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains unknown. Here, we investigated the role of exosomes in NAFLD progression. Exosomes were isolated from a human hepatoma cell line treated with palmitic acid (PA) and their miRNA profiles examined by microarray. The human hepatic stellate cell (HSC) line (LX-2) was then treated with exosome isolated from hepatocytes. Compared with controls, PA-treated hepatocytes displayed significantly increased CD36 and exosome production. The microarray analysis showed there to be distinctive miRNA expression patterns between exosomes from vehicle- and PA-treated hepatocytes. When LX-2 cells were cultured with exosomes from PA-treated hepatocytes, the expression of genes related to the development of fibrosis were significantly amplified compared to those treated with exosomes from vehicle-treated hepatocytes. In conclusion, PA treatment enhanced the production of exosomes in these hepatocytes and changed their exosomal miRNA profile. Moreover, exosomes derived from PA-treated hepatocytes caused an increase in the expression levels of fibrotic genes in HSCs. Therefore, exosomes may have important roles in the crosstalk between hepatocytes and HSCs in the progression from simple steatosis to NASH. |Animals [MESH] |Cell Line, Tumor [MESH] |Exosomes/*metabolism/ultrastructure [MESH] |Gene Expression Profiling [MESH] |Hepatic Stellate Cells/*metabolism/ultrastructure [MESH] |Hepatocytes/*drug effects/*metabolism/ultrastructure [MESH] |Humans [MESH] |Liver Cirrhosis/etiology/*metabolism [MESH] |Male [MESH] |Mice [MESH] |MicroRNAs/genetics [MESH] |Palmitic Acid/*pharmacology [MESH]Exosomes derived from palmitic acid-treated hepatocytes induce fibroti(epmc).pdf DeepDyve Pubget Overpricing