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10.1038/s41598-017-03630-y http://scihub22266oqcxt.onion/10.1038/s41598-017-03630-y C5473834!5473834!28623258     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28623258&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28623258|t=2017. Chromatin organization regulates viral egress dynamics |pdf=|usr=}}{{28623258}} gab.com Text Chromatin organization regulates viral egress dynamics JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28623258 #FOAvip Various types of DNA viruses are known to elicit the formation of a large nuclear viral replication compartment and marginalization of the cell chromatin. We used three-dimensional soft x-ray tomography, confocal and electron microscopy, combined with numerical modelling of capsid diffusion to analyse the molecular organization of chromatin in herpes simplex virus 1 infection and its effect on the transport of progeny viral capsids to the nuclear envelope. Our data showed that the formation of the viral replication compartment at late infection resulted in the enrichment of heterochromatin in the nuclear periphery accompanied by the compaction of chromatin. Random walk modelling of herpes simplex virus 1?sized particles in a three-dimensional soft x-ray tomography reconstruction of an infected cell nucleus demonstrated that the peripheral, compacted chromatin restricts viral capsid diffusion, but due to interchromatin channels capsids are able to reach the nuclear envelope, the site of their nuclear egress. Twit Text FOAVip Chromatin organization regulates viral egress dynamics ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28623258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28623258 #FOAvip English Wikipedia <ref>{{Cite pmid|28623258}}</ref> Chromatin organization regulates viral egress dynamics #MMPMID28623258 Aho V; Myllys M; Ruokolainen V; Hakanen S; Mäntylä E; Virtanen J; Hukkanen V; Kühn T; Timonen J; Mattila K; Larabell CA; Vihinen-Ranta M Sci Rep 2017[]; 7 (ä): ä PMID28623258show ga Various types of DNA viruses are known to elicit the formation of a large nuclear viral replication compartment and marginalization of the cell chromatin. We used three-dimensional soft x-ray tomography, confocal and electron microscopy, combined with numerical modelling of capsid diffusion to analyse the molecular organization of chromatin in herpes simplex virus 1 infection and its effect on the transport of progeny viral capsids to the nuclear envelope. Our data showed that the formation of the viral replication compartment at late infection resulted in the enrichment of heterochromatin in the nuclear periphery accompanied by the compaction of chromatin. Random walk modelling of herpes simplex virus 1?sized particles in a three-dimensional soft x-ray tomography reconstruction of an infected cell nucleus demonstrated that the peripheral, compacted chromatin restricts viral capsid diffusion, but due to interchromatin channels capsids are able to reach the nuclear envelope, the site of their nuclear egress. äChromatin organization regulates viral egress dynamics (epmc).pdf DeepDyve Pubget Overpricing