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10.1038/s41598-017-03855-x http://scihub22266oqcxt.onion/10.1038/s41598-017-03855-x C5473819!5473819 !28623251     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28623251 &cmd=llinks): Failed to open stream: HTTP request failed! 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Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals |pdf=|usr=}}{{28623251 }} gab.com Text Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28623251 #FOAvip To expand our knowledge of the ontogeny of the T-cell receptor (TCR) repertoire of antigen-specific T-cell subsets, we combined next-generation deep sequencing and single-cell multiplex clonotype analysis to evaluate the diversity and frequency of paired TCRs, their functions and whether clonotypic TCRs are shared among different individuals. Using an HLA-A*02-restricted cytomegalovirus (CMV) pp65-derived immunogenic peptide, we found that the more dominant pp65-specific TCR clonotypes in the blood of healthy donors have higher binding affinities for the CMV peptide and arise from clonotypes that are highly shared among individuals. Interestingly, these highly shared HLA-A*02-restricted CMV-specific TCRs were detected in a CMV-seronegative individual as well as in HLA-A*02-negative donors albeit at lower frequency. More intriguingly, these shared TCR clonotypes were abundant in the stem memory T-cell subset, and TCR diversity of the stem memory T-cell repertoire was significantly lower than in the central memory and effector memory T-cell repertoires. These results suggest that the stem memory T-cell subset may serve as a reservoir of highly shared and highly functional memory T-cells. Twit Text FOAVip Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28623251 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28623251 #FOAvip English Wikipedia <ref>{{Cite pmid|28623251 }}</ref> Highly functional T-cell receptor repertoires are abundant in stem memory T cells and highly shared among individuals #MMPMID28623251 Miyama T ; Kawase T ; Kitaura K ; Chishaki R ; Shibata M ; Oshima K ; Hamana H ; Kishi H ; Muraguchi A ; Kuzushima K ; Saji H ; Shin-I T ; Suzuki R ; Ichinohe T Sci Rep 2017[Jun]; 7 (1 ): 3663 PMID28623251 show ga To expand our knowledge of the ontogeny of the T-cell receptor (TCR) repertoire of antigen-specific T-cell subsets, we combined next-generation deep sequencing and single-cell multiplex clonotype analysis to evaluate the diversity and frequency of paired TCRs, their functions and whether clonotypic TCRs are shared among different individuals. Using an HLA-A*02-restricted cytomegalovirus (CMV) pp65-derived immunogenic peptide, we found that the more dominant pp65-specific TCR clonotypes in the blood of healthy donors have higher binding affinities for the CMV peptide and arise from clonotypes that are highly shared among individuals. Interestingly, these highly shared HLA-A*02-restricted CMV-specific TCRs were detected in a CMV-seronegative individual as well as in HLA-A*02-negative donors albeit at lower frequency. More intriguingly, these shared TCR clonotypes were abundant in the stem memory T-cell subset, and TCR diversity of the stem memory T-cell repertoire was significantly lower than in the central memory and effector memory T-cell repertoires. These results suggest that the stem memory T-cell subset may serve as a reservoir of highly shared and highly functional memory T-cells. |*Immunologic Memory [MESH] |Biomarkers [MESH] |Cell Line [MESH] |Gene Expression [MESH] |Genetic Variation [MESH] |HLA Antigens/genetics/immunology [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Immunity, Cellular [MESH] |Immunophenotyping [MESH] |Lymphocyte Activation/immunology [MESH] |Phosphoproteins/immunology [MESH] |Precursor Cells, T-Lymphoid/*immunology/*metabolism [MESH] |Receptors, Antigen, T-Cell/genetics/*metabolism [MESH] |T-Cell Antigen Receptor Specificity [MESH] |Transduction, Genetic [MESH]Highly functional T-cell receptor repertoires are abundant in stem mem(epmc).pdf DeepDyve Pubget Overpricing