Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncomms13508 http://scihub22266oqcxt.onion/10.1038/ncomms13508 C5473638!5473638!27869116     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27869116|t=2016. Autophagy controls centrosome number by degrading Cep63 |pdf=|usr=}}{{27869116}} gab.com Text Autophagy controls centrosome number by degrading Cep63 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27869116 #FOAvip Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin?proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and digested by autophagy in wild-type cells, and that the upregulation of Cep63 increases centrosome number. Cep63 is recruited to autophagosomes via interaction with p62, a molecule crucial for selective autophagy. In vivo, hematopoietic cells from autophagy-deficient and p62?/? mice also contained multiple centrosomes. These results indicate that autophagy controls centrosome number by degrading Cep63. Twit Text FOAVip Autophagy controls centrosome number by degrading Cep63 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27869116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27869116 #FOAvip English Wikipedia <ref>{{Cite pmid|27869116}}</ref> Autophagy controls centrosome number by degrading Cep63 #MMPMID27869116 Watanabe Y; Honda S; Konishi A; Arakawa S; Murohashi M; Yamaguchi H; Torii S; Tanabe M; Tanaka S; Warabi E; Shimizu S Nat Commun 2016[]; 7 (ä): ä PMID27869116show ga Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin?proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and digested by autophagy in wild-type cells, and that the upregulation of Cep63 increases centrosome number. Cep63 is recruited to autophagosomes via interaction with p62, a molecule crucial for selective autophagy. In vivo, hematopoietic cells from autophagy-deficient and p62?/? mice also contained multiple centrosomes. These results indicate that autophagy controls centrosome number by degrading Cep63. äAutophagy controls centrosome number by degrading Cep63 (epmc).pdf DeepDyve Pubget Overpricing