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2017 ; 12
(6
): e0179659
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Effect of acute predation with bacteriophage on intermicrobial aggression by
Pseudomonas aeruginosa
#MMPMID28622385
Secor PR
; Sass G
; Nazik H
; Stevens DA
PLoS One
2017[]; 12
(6
): e0179659
PMID28622385
show ga
In persons with structural lung disease, particularly those with cystic fibrosis
(CF), chronic airway infections cause progressive loss of lung function. CF
airways can be colonized by a variety of microorganisms; the most frequently
encountered bacterial and fungal pathogens are Pseudomonas aeruginosa and
Aspergillus fumigatus, respectively. Co-infection with P. aeruginosa and A.
fumigatus often results in a more rapid loss of lung function, indicating that
interactions between these pathogens affect infection pathogenesis. There has
been renewed interest in the use of viruses (bacteriophage, mycoviruses) as
alternatives to antibiotics to treat these infections. In previous work, we found
that filamentous Pf bacteriophage produced by P. aeruginosa directly inhibited
the metabolic activity of A. fumigatus by binding to and sequestering iron. In
the current study, we further examined how filamentous Pf bacteriophage affected
interactions between P. aeruginosa and A. fumigatus. Here, we report that the
antifungal properties of supernatants collected from P. aeruginosa cultures
infected with Pf bacteriophage were substantially less inhibitory towards A.
fumigatus biofilms. In particular, we found that acute infection of P. aeruginosa
by Pf bacteriophage inhibited the production of the virulence factor pyoverdine.
Our results raise the possibility that the reduced production of antimicrobials
by P. aeruginosa infected by Pf bacteriophage may promote conditions in CF
airways that allow co-infection with A. fumigatus to occur, exacerbating disease
severity. Our results also highlight the importance of considering how the use of
bacteriophage as therapeutic agents could affect the behavior and composition of
polymicrobial communities colonizing sites of chronic infection.
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