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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Pediatr+Pharmacol+Ther 2017 ; 22 (3): 218-26 Nephropedia Template TP
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Predictors of Adverse Outcomes in Children With Staphylococcus aureus Bacteremia #MMPMID28638305
Kumarachandran G; Johnson JK; Shirley DA; Graffunder E; Heil EL
J Pediatr Pharmacol Ther 2017[May]; 22 (3): 218-26 PMID28638305show ga
OBJECTIVES: Staphylococcus aureus bacteremia is a common infection, associated with significant morbidity and mortality in children. Factors associated with adverse treatment outcomes are poorly understood in the pediatric population. METHODS: Our study compared clinical and microbiologic characteristics of children admitted during a 5-year period (2007?2012) to a large university-based hospital and found to have S aureus bacteremia with outcome measures, in order to identify risk factors associated with treatment failure (defined as 30-day mortality, delayed microbiologic resolution, or recurrence of S aureus bacteremia within 60 days of completing effective antibiotic therapy). RESULTS: In all, 71 patients were found to have S aureus bacteremia, and of these, 17 patients (24%) experienced treatment failure. Based on the logistic regression model, only high vancomycin minimum inhibitory concentration in combination with a high-risk source of infection (i.e., infected graft or device, intra-abdominal infection, or respiratory tract infection) was significantly associated with risk of treatment failure. CONCLUSIONS: Infection associated with a high-risk source may increase the chance of treatment failure in pediatric patients with S aureus bacteremia. Vancomycin minimum inhibitory concentration alone was not found to be a predictor of treatment outcomes.