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10.1186/s12885-017-3391-5 http://scihub22266oqcxt.onion/10.1186/s12885-017-3391-5 C5472913!5472913 !28619077     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28619077 &cmd=llinks): Failed to open stream: HTTP request failed! 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What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group - EWING1 |pdf=|usr=}}{{28619077 }} gab.com Text What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group - EWING1 JO: BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28619077 #FOAvip BACKGROUND: Relapse in localized Ewing sarcoma patients has been a matter of concern regarding poor prognosis. Therefore, we investigated the impact of local control modality (surgery, surgery plus radiotherapy, and radiotherapy) on clinical outcomes such as survival and recurrence in patients with non-metastatic Ewing sarcoma treated on the first Brazilian Collaborative Group Trial of the Ewing Family of Tumors (EWING1). METHODS: Seventy-three patients with localized Ewing sarcoma of bone aged <?30 years were included. The treating physicians defined the modality of local control based on the recommendations of the coordinating center and the patient and tumor characteristics. Possible associations of local control modality with local failure (LF), disease-free survival (DFS), event-free survival (EFS), overall survival (OS), and clinical characteristics were analyzed. RESULTS: Mean patient age was 12.8 years (range, 2 to 25 years) and median follow-up time was 4.5 years (range, 2.3 to 6.7 years). Forty-seven patients underwent surgery, 13 received radiotherapy, and 13 received both. The 5-year EFS, OS, and DFS for all patients was 62.1%, 63.3%, and 73.1%, respectively. The 5-year cumulative incidence (CI) of LF was 7.6% for surgery, 11.1% for radiotherapy, and 0% for postoperative radiotherapy (PORT) (p = 0.61). The 5-year EFS was 71.7% for surgery, 30.8% for radiotherapy, and 64.1% for PORT (p = 0.009). CONCLUSIONS: There was a significant effect of local control modality on EFS and OS in the study. Surgery and PORT modalities yielded very close results. The group treated with radiotherapy alone had considerably worse outcomes. This may be confounded by greater risk factors in these patients. There was no significant effect of local control modality on the CI of LF and DFS. Twit Text FOAVip What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group - EWING1 ????BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=28619077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28619077 #FOAvip English Wikipedia <ref>{{Cite pmid|28619077 }}</ref> What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group - EWING1 #MMPMID28619077 Becker RG ; Gregianin LJ ; Galia CR ; Jesus-Garcia Filho R ; Toller EA ; Badell G ; Nakagawa SA ; David A ; Baptista AM ; Yonamime ES ; Serafini OA ; Penna V ; Santos JFC ; Brunetto AL BMC Cancer 2017[Jun]; 17 (1 ): 420 PMID28619077 show ga BACKGROUND: Relapse in localized Ewing sarcoma patients has been a matter of concern regarding poor prognosis. Therefore, we investigated the impact of local control modality (surgery, surgery plus radiotherapy, and radiotherapy) on clinical outcomes such as survival and recurrence in patients with non-metastatic Ewing sarcoma treated on the first Brazilian Collaborative Group Trial of the Ewing Family of Tumors (EWING1). METHODS: Seventy-three patients with localized Ewing sarcoma of bone aged |Adolescent [MESH] |Adult [MESH] |Bone Neoplasms/mortality/*pathology/*therapy [MESH] |Brazil [MESH] |Child [MESH] |Child, Preschool [MESH] |Combined Modality Therapy [MESH] |Female [MESH] |Humans [MESH] |Magnetic Resonance Imaging/methods [MESH] |Male [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH] |Proportional Hazards Models [MESH] |Sarcoma, Ewing/mortality/*pathology/*therapy [MESH] |Tomography, X-Ray Computed [MESH] |Treatment Outcome [MESH] |Tumor Burden [MESH]What is the impact of local control in Ewing sarcoma: analysis of the (epmc).pdf DeepDyve Pubget Overpricing