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10.1038/ncomms15582 http://scihub22266oqcxt.onion/10.1038/ncomms15582 C5472766!5472766!28593994     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28593994|t=2017. Protein-directed ribosomal frameshifting temporally regulates gene expression |pdf=|usr=}}{{28593994}} gab.com Text Protein-directed ribosomal frameshifting temporally regulates gene expression JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28593994 #FOAvip Programmed ?1 ribosomal frameshifting is a mechanism of gene expression, whereby specific signals within messenger RNAs direct a proportion of translating ribosomes to shift ?1?nt and continue translating in the new reading frame. Such frameshifting normally occurs at a set ratio and is utilized in the expression of many viral genes and a number of cellular genes. An open question is whether proteins might function as trans-acting switches to turn frameshifting on or off in response to cellular conditions. Here we show that frameshifting in a model RNA virus, encephalomyocarditis virus, is trans-activated by viral protein 2A. As a result, the frameshifting efficiency increases from 0 to 70% (one of the highest known in a mammalian system) over the course of infection, temporally regulating the expression levels of the viral structural and enzymatic proteins. Twit Text FOAVip Protein-directed ribosomal frameshifting temporally regulates gene expression ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28593994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28593994 #FOAvip English Wikipedia <ref>{{Cite pmid|28593994}}</ref> Protein-directed ribosomal frameshifting temporally regulates gene expression #MMPMID28593994 Napthine S; Ling R; Finch LK; Jones JD; Bell S; Brierley I; Firth AE Nat Commun 2017[]; 8 (ä): ä PMID28593994show ga Programmed ?1 ribosomal frameshifting is a mechanism of gene expression, whereby specific signals within messenger RNAs direct a proportion of translating ribosomes to shift ?1?nt and continue translating in the new reading frame. Such frameshifting normally occurs at a set ratio and is utilized in the expression of many viral genes and a number of cellular genes. An open question is whether proteins might function as trans-acting switches to turn frameshifting on or off in response to cellular conditions. Here we show that frameshifting in a model RNA virus, encephalomyocarditis virus, is trans-activated by viral protein 2A. As a result, the frameshifting efficiency increases from 0 to 70% (one of the highest known in a mammalian system) over the course of infection, temporally regulating the expression levels of the viral structural and enzymatic proteins. äProtein-directed ribosomal frameshifting temporally regulates gene exp(epmc).pdf DeepDyve Pubget Overpricing