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10.1038/ncomms15618 http://scihub22266oqcxt.onion/10.1038/ncomms15618 C5472757!5472757!28598415     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28598415|t=2017. DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity |pdf=|usr=}}{{28598415}} gab.com Text DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28598415 #FOAvip Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiation doses above 12?18 Gy in different cancer cells, and attenuates their immunogenicity by degrading DNA that accumulates in the cytosol upon radiation. Cytosolic DNA stimulates secretion of interferon-? by cancer cells following activation of the DNA sensor cGAS and its downstream effector STING. Repeated irradiation at doses that do not induce Trex1 amplifies interferon-? production, resulting in recruitment and activation of Batf3-dependent dendritic cells. This effect is essential for priming of CD8+ T cells that mediate systemic tumour rejection (abscopal effect) in the context of immune checkpoint blockade. Thus, Trex1 is an upstream regulator of radiation-driven anti-tumour immunity. Trex1 induction may guide the selection of radiation dose and fractionation in patients treated with immunotherapy. Twit Text FOAVip DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28598415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28598415 #FOAvip English Wikipedia <ref>{{Cite pmid|28598415}}</ref> DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity #MMPMID28598415 Vanpouille-Box C; Alard A; Aryankalayil MJ; Sarfraz Y; Diamond JM; Schneider RJ; Inghirami G; Coleman CN; Formenti SC; Demaria S Nat Commun 2017[]; 8 (ä): ä PMID28598415show ga Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear. We show that the DNA exonuclease Trex1 is induced by radiation doses above 12?18 Gy in different cancer cells, and attenuates their immunogenicity by degrading DNA that accumulates in the cytosol upon radiation. Cytosolic DNA stimulates secretion of interferon-? by cancer cells following activation of the DNA sensor cGAS and its downstream effector STING. Repeated irradiation at doses that do not induce Trex1 amplifies interferon-? production, resulting in recruitment and activation of Batf3-dependent dendritic cells. This effect is essential for priming of CD8+ T cells that mediate systemic tumour rejection (abscopal effect) in the context of immune checkpoint blockade. Thus, Trex1 is an upstream regulator of radiation-driven anti-tumour immunity. Trex1 induction may guide the selection of radiation dose and fractionation in patients treated with immunotherapy. äDNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogeni(epmc).pdf DeepDyve Pubget Overpricing