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10.2147/DDDT.S133069 http://scihub22266oqcxt.onion/10.2147/DDDT.S133069 C5472410!5472410 !28652704     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28652704 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Drug+Des+Devel+Ther 2017 ; 11 (ä): 1663-1671 Nephropedia Template TP {{tp|p=28652704 |t=2017. Rhein attenuates inflammation through inhibition of NF-?B and NALP3 inflammasome in vivo and in vitro |pdf=|usr=}}{{28652704 }} gab.com Text Rhein attenuates inflammation through inhibition of NF- B and NALP3 inflammasome in vivo and in vitro JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=28652704 #FOAvip Rhein is an important component in traditional Chinese herbal medicine formulations for gastrointestinal disorders, including inflammatory bowel diseases such as ulcerative colitis. In this study, we investigated the beneficial effects of rhein in inflammation models in the transgenic zebrafish line TG (corolla eGFP), in which both macrophages and neutrophils express eGFP and RAW264.7 macrophages. We found that the tail-cutting-induced migration of immune cells was significantly reduced in transgenic zebrafish treated with rhein. In addition, the production of proinflammatory cytokines, including IL-6, IL-1?, and tumor necrosis factor-?, were significantly reduced in lipopolysaccharide (LPS)-induced RAW264.7 macrophages treated with rhein. Parallel to the inhibition of proinflammatory cytokines, rhein significantly reduced phosphorylation levels of NF-?B p65 and inducible nitric oxide synthase, as well as COX-2 protein expression levels. Furthermore, rhein significantly reduced NALP3 and cleaved IL-1? expression in LPS + ATP-induced RAW264.7 macrophages. Thus, the present study demonstrates that rhein may exhibit its anti-inflammatory action via inhibition of NF-?B and NALP3 inflammasome pathways. Twit Text FOAVip Rhein attenuates inflammation through inhibition of NF- B and NALP3 inflammasome in vivo and in vitro ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=28652704 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28652704 #FOAvip English Wikipedia <ref>{{Cite pmid|28652704 }}</ref> Rhein attenuates inflammation through inhibition of NF-?B and NALP3 inflammasome in vivo and in vitro #MMPMID28652704 Ge H ; Tang H ; Liang Y ; Wu J ; Yang Q ; Zeng L ; Ma Z Drug Des Devel Ther 2017[]; 11 (ä): 1663-1671 PMID28652704 show ga Rhein is an important component in traditional Chinese herbal medicine formulations for gastrointestinal disorders, including inflammatory bowel diseases such as ulcerative colitis. In this study, we investigated the beneficial effects of rhein in inflammation models in the transgenic zebrafish line TG (corolla eGFP), in which both macrophages and neutrophils express eGFP and RAW264.7 macrophages. We found that the tail-cutting-induced migration of immune cells was significantly reduced in transgenic zebrafish treated with rhein. In addition, the production of proinflammatory cytokines, including IL-6, IL-1?, and tumor necrosis factor-?, were significantly reduced in lipopolysaccharide (LPS)-induced RAW264.7 macrophages treated with rhein. Parallel to the inhibition of proinflammatory cytokines, rhein significantly reduced phosphorylation levels of NF-?B p65 and inducible nitric oxide synthase, as well as COX-2 protein expression levels. Furthermore, rhein significantly reduced NALP3 and cleaved IL-1? expression in LPS + ATP-induced RAW264.7 macrophages. Thus, the present study demonstrates that rhein may exhibit its anti-inflammatory action via inhibition of NF-?B and NALP3 inflammasome pathways. |Adenosine Triphosphate/pharmacology [MESH] |Animals [MESH] |Animals, Genetically Modified [MESH] |Anthraquinones/*pharmacology [MESH] |Anti-Inflammatory Agents/*pharmacology [MESH] |Cell Movement/drug effects [MESH] |Cyclooxygenase 2/metabolism [MESH] |Dose-Response Relationship, Drug [MESH] |Inflammasomes/*drug effects/immunology/metabolism [MESH] |Inflammation Mediators/metabolism [MESH] |Inflammation/immunology/metabolism/*prevention & control [MESH] |Interleukin-1beta/metabolism [MESH] |Lipopolysaccharides/pharmacology [MESH] |Macrophage Activation/*drug effects [MESH] |Macrophages/*drug effects/immunology/metabolism [MESH] |Mice [MESH] |NF-kappa B/immunology/*metabolism [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/immunology/*metabolism [MESH] |Nitric Oxide Synthase Type II/metabolism [MESH] |Nitric Oxide/metabolism [MESH] |Phosphorylation [MESH] |RAW 264.7 Cells [MESH] |Signal Transduction/drug effects [MESH] |Transcription Factor RelA/metabolism [MESH]Rhein attenuates inflammation through inhibition of NF-?B and NALP3 in(epmc).pdf DeepDyve Pubget Overpricing