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10.1161/HYPERTENSIONAHA.117.09276 http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.117.09276 C5472224!5472224 !28507170     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28507170 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hypertension 2017 ; 70 (1 ): 174-182 Nephropedia Template TP {{tp|p=28507170 |t=2017. Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor ? Impairs Nuclear Export of Nuclear Factor-?B p65 in Vascular Smooth Muscle |pdf=|usr=}}{{28507170 }} gab.com Text Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor Impairs Nuclear Export of Nuclear Factor- B p65 in Vascular Smooth Muscle JO: Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=28507170 #FOAvip Selective expression of dominant negative (DN) peroxisome proliferator-activated receptor ? (PPAR?) in vascular smooth muscle cells (SMC) results in hypertension, atherosclerosis, and increased nuclear factor-?B (NF-?B) target gene expression. Mesenteric SMC were cultured from mice designed to conditionally express wild-type (WT) or DN-PPAR? in response to Cre recombinase to determine how SMC PPAR? regulates expression of NF-?B target inflammatory genes. SMC-specific overexpression of WT-PPAR? or agonist-induced activation of endogenous PPAR? blunted tumor necrosis factor ? (TNF-?)-induced NF-?B target gene expression and activity of an NF-?B-responsive promoter. TNF-?-induced gene expression responses were enhanced by DN-PPAR? in SMC. Although expression of NF-?B p65 was unchanged, nuclear export of p65 was accelerated by WT-PPAR? and prevented by DN-PPAR? in SMC. Leptomycin B, a nuclear export inhibitor, blocked p65 nuclear export and inhibited the anti-inflammatory action of PPAR?. Consistent with a role in facilitating p65 nuclear export, WT-PPAR? coimmunoprecipitated with p65, and WT-PPAR? was also exported from the nucleus after TNF-? treatment. Conversely, DN-PPAR? does not bind to p65 and was retained in the nucleus after TNF-? treatment. Transgenic mice expressing WT-PPAR? or DN-PPAR? specifically in SMC (S-WT or S-DN) were bred with mice expressing luciferase controlled by an NF-?B-responsive promoter to assess effects on NF-?B activity in whole tissue. TNF-?-induced NF-?B activity was decreased in aorta and carotid artery from S-WT but was increased in vessels from S-DN mice. We conclude that SMC PPAR? blunts expression of proinflammatory genes by inhibition of NF-?B activity through a mechanism promoting nuclear export of p65, which is abolished by DN mutation in PPAR?. Twit Text FOAVip Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor Impairs Nuclear Export of Nuclear Factor- B p65 in Vascular Smooth Muscle ????Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=28507170 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28507170 #FOAvip English Wikipedia <ref>{{Cite pmid|28507170 }}</ref> Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor ? Impairs Nuclear Export of Nuclear Factor-?B p65 in Vascular Smooth Muscle #MMPMID28507170 Mukohda M ; Lu KT ; Guo DF ; Wu J ; Keen HL ; Liu X ; Ketsawatsomkron P ; Stump M ; Rahmouni K ; Quelle FW ; Sigmund CD Hypertension 2017[Jul]; 70 (1 ): 174-182 PMID28507170 show ga Selective expression of dominant negative (DN) peroxisome proliferator-activated receptor ? (PPAR?) in vascular smooth muscle cells (SMC) results in hypertension, atherosclerosis, and increased nuclear factor-?B (NF-?B) target gene expression. Mesenteric SMC were cultured from mice designed to conditionally express wild-type (WT) or DN-PPAR? in response to Cre recombinase to determine how SMC PPAR? regulates expression of NF-?B target inflammatory genes. SMC-specific overexpression of WT-PPAR? or agonist-induced activation of endogenous PPAR? blunted tumor necrosis factor ? (TNF-?)-induced NF-?B target gene expression and activity of an NF-?B-responsive promoter. TNF-?-induced gene expression responses were enhanced by DN-PPAR? in SMC. Although expression of NF-?B p65 was unchanged, nuclear export of p65 was accelerated by WT-PPAR? and prevented by DN-PPAR? in SMC. Leptomycin B, a nuclear export inhibitor, blocked p65 nuclear export and inhibited the anti-inflammatory action of PPAR?. Consistent with a role in facilitating p65 nuclear export, WT-PPAR? coimmunoprecipitated with p65, and WT-PPAR? was also exported from the nucleus after TNF-? treatment. Conversely, DN-PPAR? does not bind to p65 and was retained in the nucleus after TNF-? treatment. Transgenic mice expressing WT-PPAR? or DN-PPAR? specifically in SMC (S-WT or S-DN) were bred with mice expressing luciferase controlled by an NF-?B-responsive promoter to assess effects on NF-?B activity in whole tissue. TNF-?-induced NF-?B activity was decreased in aorta and carotid artery from S-WT but was increased in vessels from S-DN mice. We conclude that SMC PPAR? blunts expression of proinflammatory genes by inhibition of NF-?B activity through a mechanism promoting nuclear export of p65, which is abolished by DN mutation in PPAR?. |*Hypertension/genetics/metabolism [MESH] |*Muscle, Smooth, Vascular/metabolism/physiopathology [MESH] |*NF-kappa B/antagonists & inhibitors/metabolism [MESH] |Active Transport, Cell Nucleus/drug effects [MESH] |Animals [MESH] |Anti-Inflammatory Agents/pharmacology [MESH] |Cell Nucleus/metabolism [MESH] |Cells, Cultured [MESH] |Fatty Acids, Unsaturated/pharmacology [MESH] |Inflammation/genetics/metabolism [MESH] |Mice [MESH] |Mutation [MESH] |PPAR gamma/*genetics [MESH] |Transcription Factor RelA/*metabolism [MESH]Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Rec(epmc).pdf DeepDyve Pubget Overpricing