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10.1159/000464104 http://scihub22266oqcxt.onion/10.1159/000464104 C5472216!5472216!28467993     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Arch+Allergy+Immunol ä ; 172 (4): 187-202 Nephropedia Template TP {{tp|p=28467993|t=ä. Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy |pdf=|usr=}}{{28467993}} gab.com Text Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy JO: Int Arch Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28467993 #FOAvip The years 1988?1995 witnessed the beginning of allergen cloning and the generation of recombinant allergens, which opened up new avenues for the diagnosis and research of human allergic diseases. Most crystal and solution structures of allergens have been obtained using recombinant allergens. Structural information on allergens allows insights into their evolutionary biology, illustrates clinically observed cross-reactivities, and makes the design of hypoallergenic derivatives for allergy vaccines possible. Recombinant allergens are widely used in molecule-based allergy diagnosis such as protein microarrays or suspension arrays. Recombinant technologies have been used to produce well-characterized, noncontaminated vaccine components with known biological activities including a variety of allergen derivatives with reduced IgE reactivity. Such recombinant hypoallergens as well as wild-type recombinant allergens have been used successfully in several immunotherapy trials for more than a decade to treat birch and grass pollen allergy. As a more recent application, the development of antibody repertoires directed against conformational epitopes during immunotherapy has been monitored by recombinant allergen chimeras. Although much progress has been made, the number and quality of recombinant allergens will undoubtedly increase and keep improving our knowledge in basic scientific investigations, diagnosis, and therapy of human allergic diseases. Twit Text FOAVip Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy ????Int Arch Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28467993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28467993 #FOAvip English Wikipedia <ref>{{Cite pmid|28467993}}</ref> Recombinant Allergens in Structural Biology, Diagnosis, and Immunotherapy #MMPMID28467993 Tscheppe A; Breiteneder H Int Arch Allergy Immunol ä[]; 172 (4): 187-202 PMID28467993show ga The years 1988?1995 witnessed the beginning of allergen cloning and the generation of recombinant allergens, which opened up new avenues for the diagnosis and research of human allergic diseases. Most crystal and solution structures of allergens have been obtained using recombinant allergens. Structural information on allergens allows insights into their evolutionary biology, illustrates clinically observed cross-reactivities, and makes the design of hypoallergenic derivatives for allergy vaccines possible. Recombinant allergens are widely used in molecule-based allergy diagnosis such as protein microarrays or suspension arrays. Recombinant technologies have been used to produce well-characterized, noncontaminated vaccine components with known biological activities including a variety of allergen derivatives with reduced IgE reactivity. Such recombinant hypoallergens as well as wild-type recombinant allergens have been used successfully in several immunotherapy trials for more than a decade to treat birch and grass pollen allergy. As a more recent application, the development of antibody repertoires directed against conformational epitopes during immunotherapy has been monitored by recombinant allergen chimeras. Although much progress has been made, the number and quality of recombinant allergens will undoubtedly increase and keep improving our knowledge in basic scientific investigations, diagnosis, and therapy of human allergic diseases. äRecombinant Allergens in Structural Biology, Diagnosis, and Immunother(epmc).pdf DeepDyve Pubget Overpricing