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10.1038/ncomms15502 http://scihub22266oqcxt.onion/10.1038/ncomms15502 C5472178!5472178 !28593998     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28593998 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 15502 Nephropedia Template TP {{tp|p=28593998 |t=2017. The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation |pdf=|usr=}}{{28593998 }} gab.com Text The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28593998 #FOAvip Caveolin-1 (CAV1), the major constituent of caveolae, plays a pivotal role in various cellular biological functions, including cancer and inflammation. The ubiquitin/proteasomal pathway is known to contribute to the regulation of CAV1 expression, but the ubiquitin ligase responsible for CAV1 protein stability remains unidentified. Here we reveal that E3 ubiquitin ligase ZNRF1 modulates CAV1 protein stability to regulate Toll-like receptor (TLR) 4-triggered immune responses. We demonstrate that ZNRF1 physically interacts with CAV1 in response to lipopolysaccharide and mediates ubiquitination and degradation of CAV1. The ZNRF1-CAV1 axis regulates Akt-GSK3? activity upon TLR4 activation, resulting in enhanced production of pro-inflammatory cytokines and inhibition of anti-inflammatory cytokine IL-10. Mice with deletion of ZNRF1 in their hematopoietic cells display increased resistance to endotoxic and polymicrobial septic shock due to attenuated inflammation. Our study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1. Twit Text FOAVip The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28593998 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28593998 #FOAvip English Wikipedia <ref>{{Cite pmid|28593998 }}</ref> The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation #MMPMID28593998 Lee CY ; Lai TY ; Tsai MK ; Chang YC ; Ho YH ; Yu IS ; Yeh TW ; Chou CC ; Lin YS ; Lawrence T ; Hsu LC Nat Commun 2017[Jun]; 8 (ä): 15502 PMID28593998 show ga Caveolin-1 (CAV1), the major constituent of caveolae, plays a pivotal role in various cellular biological functions, including cancer and inflammation. The ubiquitin/proteasomal pathway is known to contribute to the regulation of CAV1 expression, but the ubiquitin ligase responsible for CAV1 protein stability remains unidentified. Here we reveal that E3 ubiquitin ligase ZNRF1 modulates CAV1 protein stability to regulate Toll-like receptor (TLR) 4-triggered immune responses. We demonstrate that ZNRF1 physically interacts with CAV1 in response to lipopolysaccharide and mediates ubiquitination and degradation of CAV1. The ZNRF1-CAV1 axis regulates Akt-GSK3? activity upon TLR4 activation, resulting in enhanced production of pro-inflammatory cytokines and inhibition of anti-inflammatory cytokine IL-10. Mice with deletion of ZNRF1 in their hematopoietic cells display increased resistance to endotoxic and polymicrobial septic shock due to attenuated inflammation. Our study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1. |*Proteolysis [MESH] |*Ubiquitination [MESH] |Amino Acid Sequence [MESH] |Animals [MESH] |Caveolin 1/chemistry/*metabolism [MESH] |Cecum/pathology [MESH] |Cyclic AMP Response Element-Binding Protein/metabolism [MESH] |Gene Deletion [MESH] |Glycogen Synthase Kinase 3 beta/metabolism [MESH] |Inflammation Mediators/metabolism [MESH] |Inflammation/*metabolism/*pathology [MESH] |Ligation [MESH] |Lipopolysaccharides [MESH] |Lysine/metabolism [MESH] |Macrophages/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Protein Binding [MESH] |Protein Stability [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Punctures [MESH] |RAW 264.7 Cells [MESH] |Shock, Septic/immunology/metabolism/pathology [MESH] |Signal Transduction [MESH] |Toll-Like Receptor 4/metabolism [MESH]The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degr(epmc).pdf DeepDyve Pubget Overpricing