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10.1038/ncomms15509 http://scihub22266oqcxt.onion/10.1038/ncomms15509 C5472175!5472175!28593951     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28593951|t=2017. Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information |pdf=|usr=}}{{28593951}} gab.com Text Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28593951 #FOAvip Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis. Here we developed an electrospun membrane biofunctionalized with a fragment of the laminin ?1-chain to modulate the expression of MMP2 in this context. We demonstrate that interfacing of the ?1-fragment with the mesothelium of the peritoneal membrane via a biomaterial abrogates the release of active MMP2 in response to transforming growth factor ?1 and rescues tissue integrity ex vivo and in vivo in a mouse model of peritoneal fibrosis. Importantly, our data demonstrate that the membrane inhibits MMP2 expression. Changes in the expression of epithelial-to-mesenchymal transition (EMT)-related molecules further point towards a contribution of the modulation of EMT. Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations of current therapeutic approaches by enabling a localized and specific method to counteract MMP2 release applicable to a broad range of therapeutic targets. Twit Text FOAVip Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28593951 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28593951 #FOAvip English Wikipedia <ref>{{Cite pmid|28593951}}</ref> Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information #MMPMID28593951 Horejs CM; St-Pierre JP; Ojala JRM; Steele JAM; da Silva PB; Rynne-Vidal A; Maynard SA; Hansel CS; Rodríguez-Fernández C; Mazo MM; You AYF; Wang AJ; von Erlach T; Tryggvason K; López-Cabrera M; Stevens MM Nat Commun 2017[]; 8 (ä): ä PMID28593951show ga Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis. Here we developed an electrospun membrane biofunctionalized with a fragment of the laminin ?1-chain to modulate the expression of MMP2 in this context. We demonstrate that interfacing of the ?1-fragment with the mesothelium of the peritoneal membrane via a biomaterial abrogates the release of active MMP2 in response to transforming growth factor ?1 and rescues tissue integrity ex vivo and in vivo in a mouse model of peritoneal fibrosis. Importantly, our data demonstrate that the membrane inhibits MMP2 expression. Changes in the expression of epithelial-to-mesenchymal transition (EMT)-related molecules further point towards a contribution of the modulation of EMT. Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations of current therapeutic approaches by enabling a localized and specific method to counteract MMP2 release applicable to a broad range of therapeutic targets. äPreventing tissue fibrosis by local biomaterials interfacing of specif(epmc).pdf DeepDyve Pubget Overpricing