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10.1186/s12859-017-1636-6 http://scihub22266oqcxt.onion/10.1186/s12859-017-1636-6 C5471961!5471961!28617232     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Bioinformatics 2017 ; 18 (Suppl 7): ä Nephropedia Template TP {{tp|p=28617232|t=2017. TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network |pdf=|usr=}}{{28617232}} gab.com Text TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network JO: BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=28617232 #FOAvip Background: Transcription factor (TF) networks play a key role in controlling the transfer of genetic information from gene to mRNA. Much progress has been made on understanding and reverse-engineering TF network topologies using a range of experimental and theoretical methodologies. Less work has focused on using these models to examine how TF networks respond to changes in the cellular environment. Methods: In this paper, we have developed a simple, pragmatic methodology, TIGERi (Transcription-factor-activity Illustrator for Global Explanation of Regulatory interaction), to model the response of an inferred TF network to changes in cellular environment. The methodology was tested using publicly available data comparing gene expression profiles of a mouse p38? (Mapk14) knock-out line to the original wild-type. Results: Using the model, we have examined changes in the TF network resulting from the presence or absence of p38?. A part of this network was confirmed by experimental work in the original paper. Additional relationships were identified by our analysis, for example between p38? and HNF3, and between p38? and SOX9, and these are strongly supported by published evidence. FXR and MYC were also discovered in our analysis as two novel links of p38?. To provide a computational methodology to the biomedical communities that has more user-friendly interface, we also developed a standalone GUI (graphical user interface) software for TIGERi and it is freely available at https://github.com/namshik/tigeri/. Conclusions: We therefore believe that our computational approach can identify new members of networks and new interactions between members that are supported by published data but have not been integrated into the existing network models. Moreover, ones who want to analyze their own data with TIGERi could use the software without any command line experience. This work could therefore accelerate researches in transcriptional gene regulation in higher eukaryotes. Electronic supplementary material: The online version of this article (doi:10.1186/s12859-017-1636-6) contains supplementary material, which is available to authorized users. Twit Text FOAVip TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network ????BMC Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=28617232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28617232 #FOAvip English Wikipedia <ref>{{Cite pmid|28617232}}</ref> TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network #MMPMID28617232 Han N; Noyes HA; Brass A BMC Bioinformatics 2017[]; 18 (Suppl 7): ä PMID28617232show ga Background: Transcription factor (TF) networks play a key role in controlling the transfer of genetic information from gene to mRNA. Much progress has been made on understanding and reverse-engineering TF network topologies using a range of experimental and theoretical methodologies. Less work has focused on using these models to examine how TF networks respond to changes in the cellular environment. Methods: In this paper, we have developed a simple, pragmatic methodology, TIGERi (Transcription-factor-activity Illustrator for Global Explanation of Regulatory interaction), to model the response of an inferred TF network to changes in cellular environment. The methodology was tested using publicly available data comparing gene expression profiles of a mouse p38? (Mapk14) knock-out line to the original wild-type. Results: Using the model, we have examined changes in the TF network resulting from the presence or absence of p38?. A part of this network was confirmed by experimental work in the original paper. Additional relationships were identified by our analysis, for example between p38? and HNF3, and between p38? and SOX9, and these are strongly supported by published evidence. FXR and MYC were also discovered in our analysis as two novel links of p38?. To provide a computational methodology to the biomedical communities that has more user-friendly interface, we also developed a standalone GUI (graphical user interface) software for TIGERi and it is freely available at https://github.com/namshik/tigeri/. Conclusions: We therefore believe that our computational approach can identify new members of networks and new interactions between members that are supported by published data but have not been integrated into the existing network models. Moreover, ones who want to analyze their own data with TIGERi could use the software without any command line experience. This work could therefore accelerate researches in transcriptional gene regulation in higher eukaryotes. Electronic supplementary material: The online version of this article (doi:10.1186/s12859-017-1636-6) contains supplementary material, which is available to authorized users. äTIGERi: modeling and visualizing the responses to perturbation of a tr(epmc).pdf DeepDyve Pubget Overpricing