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Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biomark 2017 ; 2017 (ä): ä Nephropedia Template TP
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The Circadian Rhythm of Copeptin, the C-Terminal Portion of Arginine Vasopressin #MMPMID28656120
Beglinger S; Drewe J; Christ-Crain M
J Biomark 2017[]; 2017 (ä): ä PMID28656120show ga
Background: Several studies have investigated copeptin as a prognostic marker of different acute diseases and as a diagnostic marker in disorders of water and salt homeostasis. However, no data of the normal circadian rhythm of copeptin in healthy subjects are available. Aim: To investigate the circadian rhythm of copeptin in healthy subjects under standardized conditions. Methods: 19 healthy volunteers aged 18 to 53 years, male and female, were studied in a prospective observational study. In all 19 participants, blood samples for copeptin were taken in regular intervals of 30 minutes for 24 hours after a fasting period of minimum 8 hours. Results: The mean values of copeptin showed a circadian rhythm, similar to that described for AVP release, with a trend towards higher levels (5.9 ± 1?pmol/L) at night and early morning between 4 am and 6 am and lowest levels (2.3 ± 0.2?pmol/L) in the late afternoon between 5 pm and 7 pm. This finding was only observed in individuals with initial higher copeptin levels, whereas in individuals with lower basal copeptin levels no circadian rhythm was observed. Conclusion: There is evidence for a circadian rhythm in copeptin release during 24 hours, however, of minor extent. These findings suggest that copeptin levels can be determined irrespectively of the time of the day.