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10.1038/nsmb.3336 http://scihub22266oqcxt.onion/10.1038/nsmb.3336 C5471492!5471492!27941862     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Struct+Mol+Biol 2017 ; 24 (1): 40-6 Nephropedia Template TP {{tp|p=27941862|t=2017. Cryo-EM structures of human recombinase RAD51 filaments in the catalysis of DNA strand exchange |pdf=|usr=}}{{27941862}} gab.com Text Cryo-EM structures of human recombinase RAD51 filaments in the catalysis of DNA strand exchange JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=27941862 #FOAvip The central step in eukaryotic homologous recombination (HR) is ATP-dependent DNA strand exchange mediated by the Rad51 recombinase. In this process, Rad51 assembles on single-stranded DNA (ssDNA) to yield a helical filament that is able to search for and invade a homologous double-stranded DNA (dsDNA), leading to strand separation in the dsDNA and formation of new base pairs between the initiating ssDNA and the complementary strand in the duplex partner. Here we have used cryo-electron microscopy (cryo-EM) to solve the structures of human RAD51 in complex with DNA molecules in their presynaptic and post-synaptic states at near atomic resolution. Our structures revealed both conserved and distinct structural features of the RAD51-DNA complexes in comparison with its prokaryotic counterpart. Importantly, we have also captured the structure of an arrested synaptic complex. The results provide insights into the molecular mechanism of DNA homology search and strand exchange processes. Twit Text FOAVip Cryo-EM structures of human recombinase RAD51 filaments in the catalysis of DNA strand exchange ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=27941862 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27941862 #FOAvip English Wikipedia <ref>{{Cite pmid|27941862}}</ref> Cryo-EM structures of human recombinase RAD51 filaments in the catalysis of DNA strand exchange #MMPMID27941862 Xu J; Zhao L; Xu Y; Zhao W; Sung P; Wang HW Nat Struct Mol Biol 2017[Jan]; 24 (1): 40-6 PMID27941862show ga The central step in eukaryotic homologous recombination (HR) is ATP-dependent DNA strand exchange mediated by the Rad51 recombinase. In this process, Rad51 assembles on single-stranded DNA (ssDNA) to yield a helical filament that is able to search for and invade a homologous double-stranded DNA (dsDNA), leading to strand separation in the dsDNA and formation of new base pairs between the initiating ssDNA and the complementary strand in the duplex partner. Here we have used cryo-electron microscopy (cryo-EM) to solve the structures of human RAD51 in complex with DNA molecules in their presynaptic and post-synaptic states at near atomic resolution. Our structures revealed both conserved and distinct structural features of the RAD51-DNA complexes in comparison with its prokaryotic counterpart. Importantly, we have also captured the structure of an arrested synaptic complex. The results provide insights into the molecular mechanism of DNA homology search and strand exchange processes. äCryo-EM structures of human recombinase RAD51 filaments in the catalys(epmc).pdf DeepDyve Pubget Overpricing