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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Oxf+Med+Case+Reports 2017 ; 2017 (6): ä Nephropedia Template TP
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Kikuchi?Fujimoto disease: a case report of a multi-drug resistant, grueling disease #MMPMID28638624
Youssef A; Ali R; Ali K; AlShehabi Z
Oxf Med Case Reports 2017[Jun]; 2017 (6): ä PMID28638624show ga
Histiocytic necrotizing lymphadenitis or Kikuchi?Fujimoto disease (KFD) is characterized by its rare occurrence. Mostly prevalent among Asian women, KFD manifests with lymphadenopathy?affecting mostly cervical and rarely generalized or retroperitoneal regions?in addition to fever. It is a self-limited disease that resolves within 1?4 months, responding remarkably to glucocorticosteroids or hydroxychloroquine. However, some rare cases prove to be unresponsive to the previously mentioned therapies. Here is a description of a case of KFD affecting a 67-year-old Syrian woman with a history of hypothyroidism due to iodine-deficiency. The patient?s initial clinical picture was malaise, fever, pericarditis and generalized lymphadenopathy. As treatment, she was given glucocorticosteroids with no significant response, while hydroxychloroquine proved to be partially effective. Until the date of this report, she has been receiving hydroxychloroquine with only slight clinical improvement. This case is proving to be resistant unlike most KFD cases that generally respond very well to treatment.