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10.3389/fmed.2017.00073 http://scihub22266oqcxt.onion/10.3389/fmed.2017.00073 C5471312!5471312!28664159     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Med+(Lausanne) 2017 ; 4 (ä): ä Nephropedia Template TP {{tp|p=28664159|t=2017. Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases |pdf=|usr=}}{{28664159}} gab.com Text Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases JO: Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=28664159 #FOAvip There is currently an unmet need for better biomarkers across the spectrum of renal diseases. In this paper, we revisit the role of beta-2 microglobulin (?2M) as a biomarker in patients with chronic kidney disease and end-stage renal disease. Prior to reviewing the numerous clinical studies in the area, we describe the basic biology of ?2M, focusing in particular on its role in maintaining the serum albumin levels and reclaiming the albumin in tubular fluid through the actions of the neonatal Fc receptor. Disorders of abnormal ?2M function arise as a result of altered binding of ?2M to its protein cofactors and the clinical manifestations are exemplified by rare human genetic conditions and mice knockouts. We highlight the utility of ?2M as a predictor of renal function and clinical outcomes in recent large database studies against predictions made by recently developed whole body population kinetic models. Furthermore, we discuss recent animal data suggesting that contrary to textbook dogma urinary ?2M may be a marker for glomerular rather than tubular pathology. We review the existing literature about ?2M as a biomarker in patients receiving renal replacement therapy, with particular emphasis on large outcome trials. We note emerging proteomic data suggesting that ?2M is a promising marker of chronic allograft nephropathy. Finally, we present data about the role of ?2M as a biomarker in a number of non-renal diseases. The goal of this comprehensive review is to direct attention to the multifaceted role of ?2M as a biomarker, and its exciting biology in order to propose the next steps required to bring this recently rediscovered biomarker into the twenty-first century. Twit Text FOAVip Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases ????Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=28664159 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28664159 #FOAvip English Wikipedia <ref>{{Cite pmid|28664159}}</ref> Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases #MMPMID28664159 Argyropoulos CP; Chen SS; Ng YH; Roumelioti ME; Shaffi K; Singh PP; Tzamaloukas AH Front Med (Lausanne) 2017[]; 4 (ä): ä PMID28664159show ga There is currently an unmet need for better biomarkers across the spectrum of renal diseases. In this paper, we revisit the role of beta-2 microglobulin (?2M) as a biomarker in patients with chronic kidney disease and end-stage renal disease. Prior to reviewing the numerous clinical studies in the area, we describe the basic biology of ?2M, focusing in particular on its role in maintaining the serum albumin levels and reclaiming the albumin in tubular fluid through the actions of the neonatal Fc receptor. Disorders of abnormal ?2M function arise as a result of altered binding of ?2M to its protein cofactors and the clinical manifestations are exemplified by rare human genetic conditions and mice knockouts. We highlight the utility of ?2M as a predictor of renal function and clinical outcomes in recent large database studies against predictions made by recently developed whole body population kinetic models. Furthermore, we discuss recent animal data suggesting that contrary to textbook dogma urinary ?2M may be a marker for glomerular rather than tubular pathology. We review the existing literature about ?2M as a biomarker in patients receiving renal replacement therapy, with particular emphasis on large outcome trials. We note emerging proteomic data suggesting that ?2M is a promising marker of chronic allograft nephropathy. Finally, we present data about the role of ?2M as a biomarker in a number of non-renal diseases. The goal of this comprehensive review is to direct attention to the multifaceted role of ?2M as a biomarker, and its exciting biology in order to propose the next steps required to bring this recently rediscovered biomarker into the twenty-first century. äRediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum (epmc).pdf DeepDyve Pubget Overpricing