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2017 ; 7
(1
): 3486
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Glucocorticoids ameliorate TGF-?1-mediated epithelial-to-mesenchymal transition
of airway epithelium through MAPK and Snail/Slug signaling pathways
#MMPMID28615628
Yang HW
; Lee SA
; Shin JM
; Park IH
; Lee HM
Sci Rep
2017[Jun]; 7
(1
): 3486
PMID28615628
show ga
Chronic rhinosinusitis with nasal polyps (CRSwNP) is closely associated with
tissue remodeling. Epithelial-to-mesenchymal transition (EMT), a process of
tissue remodeling, can be a therapeutic target of CRSwNP. Glucocorticoids are a
type of steroid hormone that is used primarily in medical therapy for patients
with CRSwNP; however, their effects on EMT in the airway epithelium remain
unknown. To investigate the effects of dexamethasone and fluticasone propionate,
a class of glucocorticoids, on transforming growth factor-?1 (TGF-?1) -induced
EMT, we used A549 cells, human primary nasal epithelial cells (hPNECs) and ex
vivo organ culture of the inferior turbinate. TGF-?1 induced changes in cell
morphology, suppressed the expression of E-cadherin and enhanced the expression
of a-smooth muscle actin, vimentin and fibronectin in A549 cells. However,
glucocorticoids inhibited EMT, migration and invasion enhancement by TGF-?1. We
found that the induction of phosphorylated ERK, p38 and the activity of Snail and
Slug transcription factors by TGF-?1 were suppressed by glucocorticoids.
Glucocorticoids also had a similar effect in hPNECs and ex vivo organ cultures of
the inferior turbinate. These findings suggest that glucocorticoids might be a
useful therapy for preventing tissue remodeling by blocking the EMT initiated by
TGF-?1-induced MAPK and Snail/Slug signaling pathways in CRSwNP.
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