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10.1038/s41598-017-03492-4

http://scihub22266oqcxt.onion/10.1038/s41598-017-03492-4
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C5471247!5471247!28615645
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suck abstract from ncbi


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pmid28615645      Sci+Rep 2017 ; 7 (ä): ä
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  • Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis #MMPMID28615645
  • Kim J; Lindsey BD; Chang WY; Dai X; Stavas JM; Dayton PA; Jiang X
  • Sci Rep 2017[]; 7 (ä): ä PMID28615645show ga
  • Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7?±?0.15 percent mass loss/min in vitro without any use of thrombolytic drugs.
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