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10.1038/s41598-017-03675-z http://scihub22266oqcxt.onion/10.1038/s41598-017-03675-z C5471224!5471224 !28615649     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28615649 &cmd=llinks): Failed to open stream: HTTP request failed! 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Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis |pdf=|usr=}}{{28615649 }} gab.com Text Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28615649 #FOAvip Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-?B. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate the effects of ANDRO in NASH and its influence on inflammasome activation in this setting. Thus, mice were fed a choline-deficient-amino-acid-defined (CDAA) diet with/without concomitant ANDRO administration (1?mg/kg, 3-times/week). Also, we assessed serum levels of alanine-aminotransferase (ALT), liver histology, hepatic triglyceride content (HTC) and hepatic expression of pro-inflammatory, pro-fibrotic and inflammasome genes. Inflammasome activation was also evaluated in fat-laden HepG2 cells. Our results showed that ANDRO administration decreased HTC and attenuated hepatic inflammation and fibrosis in CDAA-fed mice. ANDRO treatment determined a strong reduction in hepatic macrophage infiltration and reduced hepatic mRNA levels of both pro-inflammatory and pro-fibrotic genes. In addition, mice treated with ANDRO showed reduced expression of inflammasome genes. Finally, ANDRO inhibited LPS-induced interleukin-1? expression through NF-?B inhibition in fat-laden HepG2 cells and inflammasome disassembly. In conclusion, ANDRO administration reduces inflammation and fibrosis in experimental NASH. Inflammasome modulation by a NF-?B-dependent mechanism may be involved in the therapeutic effects of ANDRO. Twit Text FOAVip Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28615649 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28615649 #FOAvip English Wikipedia <ref>{{Cite pmid|28615649 }}</ref> Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis #MMPMID28615649 Cabrera D ; Wree A ; Povero D ; Solís N ; Hernandez A ; Pizarro M ; Moshage H ; Torres J ; Feldstein AE ; Cabello-Verrugio C ; Brandan E ; Barrera F ; Arab JP ; Arrese M Sci Rep 2017[Jun]; 7 (1 ): 3491 PMID28615649 show ga Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-?B. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate the effects of ANDRO in NASH and its influence on inflammasome activation in this setting. Thus, mice were fed a choline-deficient-amino-acid-defined (CDAA) diet with/without concomitant ANDRO administration (1?mg/kg, 3-times/week). Also, we assessed serum levels of alanine-aminotransferase (ALT), liver histology, hepatic triglyceride content (HTC) and hepatic expression of pro-inflammatory, pro-fibrotic and inflammasome genes. Inflammasome activation was also evaluated in fat-laden HepG2 cells. Our results showed that ANDRO administration decreased HTC and attenuated hepatic inflammation and fibrosis in CDAA-fed mice. ANDRO treatment determined a strong reduction in hepatic macrophage infiltration and reduced hepatic mRNA levels of both pro-inflammatory and pro-fibrotic genes. In addition, mice treated with ANDRO showed reduced expression of inflammasome genes. Finally, ANDRO inhibited LPS-induced interleukin-1? expression through NF-?B inhibition in fat-laden HepG2 cells and inflammasome disassembly. In conclusion, ANDRO administration reduces inflammation and fibrosis in experimental NASH. Inflammasome modulation by a NF-?B-dependent mechanism may be involved in the therapeutic effects of ANDRO. |Animals [MESH] |Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage [MESH] |Cells, Cultured [MESH] |Diterpenes/*administration & dosage [MESH] |Fibrosis/prevention & control [MESH] |Inflammasomes/*metabolism [MESH] |Inflammation/complications/metabolism/*prevention & control [MESH] |Macrophages/drug effects [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |NF-kappa B/metabolism [MESH] |Non-alcoholic Fatty Liver Disease/*complications [MESH]Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuat(epmc).pdf DeepDyve Pubget Overpricing