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10.18632/oncotarget.16470 http://scihub22266oqcxt.onion/10.18632/oncotarget.16470 C5471049!5471049 !28415638     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28415638 &cmd=llinks): Failed to open stream: HTTP request failed! 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Altered long non-coding RNAs predict worse outcome in osteosarcoma patients: evidence from a meta-analysis |pdf=|usr=}}{{28415638 }} gab.com Text Altered long non-coding RNAs predict worse outcome in osteosarcoma patients: evidence from a meta-analysis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28415638 #FOAvip Long non-coding RNAs (lncRNAs) are emerging as promising prognostic biomarkers in an expanding list of malignant neoplasms. Here, we sought to investigate the strength of associations between lncRNA signatures and clinical outcomes in osteosarcoma. We conducted a systematic search of the online databases from inception to July 2016. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for the primary endpoints of overall survival (OS), progression-free survival (PFS) or event-free survival (EFS) were extracted and meta-analyzed. Our results manifested that altered lncRNAs expression was markedly associated with worse OS (univariate analysis: HR = 3.20, 95% CI: 2.42-4.24, P = 0.000; multivariate analysis: HR = 2.66, 95% CI: 1.92-3.69, P = 0.000), PFS (HR = 2.05, 95% CI: 1.32-3.18, P = 0.001) and EFS (HR = 4.37, 95% CI: 1.64-11.66, P = 0.003) times among osteosarcoma patients. In the pooled analyses stratified by clinicopathological features, levels of lncRNAs were closely correlated with tumor size (pooled P = 0.001), tumor stage (pooled P = 0.003), and distant metastasis (pooled P = 0.002) in osteosarcoma. The results obtained in our work suggest that altered lncRNA signatures predict unfavorable clinical outcomes and are acceptable to be potential prognostic biomarkers in forecasting prognosis of osteosarcoma. Twit Text FOAVip Altered long non-coding RNAs predict worse outcome in osteosarcoma patients: evidence from a meta-analysis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28415638 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28415638 #FOAvip English Wikipedia <ref>{{Cite pmid|28415638 }}</ref> Altered long non-coding RNAs predict worse outcome in osteosarcoma patients: evidence from a meta-analysis #MMPMID28415638 Yang Y ; Wang S ; Li T Oncotarget 2017[May]; 8 (21 ): 35234-35243 PMID28415638 show ga Long non-coding RNAs (lncRNAs) are emerging as promising prognostic biomarkers in an expanding list of malignant neoplasms. Here, we sought to investigate the strength of associations between lncRNA signatures and clinical outcomes in osteosarcoma. We conducted a systematic search of the online databases from inception to July 2016. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) for the primary endpoints of overall survival (OS), progression-free survival (PFS) or event-free survival (EFS) were extracted and meta-analyzed. Our results manifested that altered lncRNAs expression was markedly associated with worse OS (univariate analysis: HR = 3.20, 95% CI: 2.42-4.24, P = 0.000; multivariate analysis: HR = 2.66, 95% CI: 1.92-3.69, P = 0.000), PFS (HR = 2.05, 95% CI: 1.32-3.18, P = 0.001) and EFS (HR = 4.37, 95% CI: 1.64-11.66, P = 0.003) times among osteosarcoma patients. In the pooled analyses stratified by clinicopathological features, levels of lncRNAs were closely correlated with tumor size (pooled P = 0.001), tumor stage (pooled P = 0.003), and distant metastasis (pooled P = 0.002) in osteosarcoma. The results obtained in our work suggest that altered lncRNA signatures predict unfavorable clinical outcomes and are acceptable to be potential prognostic biomarkers in forecasting prognosis of osteosarcoma. |Bone Neoplasms/epidemiology/genetics/*pathology [MESH] |Female [MESH] |Genetic Variation [MESH] |Humans [MESH] |Male [MESH] |Neoplasm Staging [MESH] |Osteosarcoma/epidemiology/genetics/*pathology [MESH] |Prognosis [MESH] |RNA, Long Noncoding/*genetics [MESH] |Survival Analysis [MESH]Altered long non-coding RNAs predict worse outcome in osteosarcoma pat(epmc).pdf DeepDyve Pubget Overpricing