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10.18632/oncotarget.16573 http://scihub22266oqcxt.onion/10.18632/oncotarget.16573 C5470960!5470960 !28388547     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28388547 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (21 ): 34191-34204 Nephropedia Template TP {{tp|p=28388547 |t=2017. Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545 |pdf=|usr=}}{{28388547 }} gab.com Text Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28388547 #FOAvip Despite the high prevalence of acute kidney injury (AKI) and its association with increased morbidity and mortality, therapeutic approaches for AKI are disappointing. This is largely attributed to poor understanding of the pathogenesis of AKI. Heparanase, an endoglycosidase that cleaves heparan sulfate, is involved in extracellular matrix turnover, inflammation, kidney dysfunction, diabetes, fibrosis, angiogenesis and cancer progression. The current study examined the involvement of heparanase in the pathogenesis of ischemic reperfusion (I/R) AKI in a mouse model and the protective effect of PG545, a potent heparanase inhibitor. I/R induced tubular damage and elevation in serum creatinine and blood urea nitrogen to a higher extent in heparanase over-expressing transgenic mice vs. wild type mice. Moreover, TGF-?, vimentin, fibronectin and ?-smooth muscle actin, biomarkers of fibrosis, and TNF?, IL6 and endothelin-1, biomarkers of inflammation, were upregulated in I/R induced AKI, primarily in heparanase transgenic mice, suggesting an adverse role of heparanase in the pathogenesis of AKI. Remarkably, pretreatment of mice with PG545 abolished kidney dysfunction and the up-regulation of heparanase, pro-inflammatory (i.e., IL-6) and pro-fibrotic (i.e., TGF-?) genes induced by I/R. The present study provides new insights into the involvement of heparanase in the pathogenesis of ischemic AKI.Our results demonstrate that heparanase plays a deleterious role in the development of renal injury and kidney dysfunction,attesting heparanase inhibition as a promising therapeutic approach for AKI. Twit Text FOAVip Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28388547 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28388547 #FOAvip English Wikipedia <ref>{{Cite pmid|28388547 }}</ref> Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545 #MMPMID28388547 Abassi Z ; Hamoud S ; Hassan A ; Khamaysi I ; Nativ O ; Heyman SN ; Muhammad RS ; Ilan N ; Singh P ; Hammond E ; Zaza G ; Lupo A ; Onisto M ; Bellin G ; Masola V ; Vlodavsky I ; Gambaro G Oncotarget 2017[May]; 8 (21 ): 34191-34204 PMID28388547 show ga Despite the high prevalence of acute kidney injury (AKI) and its association with increased morbidity and mortality, therapeutic approaches for AKI are disappointing. This is largely attributed to poor understanding of the pathogenesis of AKI. Heparanase, an endoglycosidase that cleaves heparan sulfate, is involved in extracellular matrix turnover, inflammation, kidney dysfunction, diabetes, fibrosis, angiogenesis and cancer progression. The current study examined the involvement of heparanase in the pathogenesis of ischemic reperfusion (I/R) AKI in a mouse model and the protective effect of PG545, a potent heparanase inhibitor. I/R induced tubular damage and elevation in serum creatinine and blood urea nitrogen to a higher extent in heparanase over-expressing transgenic mice vs. wild type mice. Moreover, TGF-?, vimentin, fibronectin and ?-smooth muscle actin, biomarkers of fibrosis, and TNF?, IL6 and endothelin-1, biomarkers of inflammation, were upregulated in I/R induced AKI, primarily in heparanase transgenic mice, suggesting an adverse role of heparanase in the pathogenesis of AKI. Remarkably, pretreatment of mice with PG545 abolished kidney dysfunction and the up-regulation of heparanase, pro-inflammatory (i.e., IL-6) and pro-fibrotic (i.e., TGF-?) genes induced by I/R. The present study provides new insights into the involvement of heparanase in the pathogenesis of ischemic AKI.Our results demonstrate that heparanase plays a deleterious role in the development of renal injury and kidney dysfunction,attesting heparanase inhibition as a promising therapeutic approach for AKI. |*Up-Regulation [MESH] |Acute Kidney Injury/drug therapy/genetics/metabolism/*pathology [MESH] |Animals [MESH] |Biomarkers/metabolism [MESH] |Disease Models, Animal [MESH] |Epithelial-Mesenchymal Transition [MESH] |Glucuronidase/antagonists & inhibitors/*genetics/*metabolism [MESH] |Humans [MESH] |Kidney/drug effects/metabolism/physiopathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Reperfusion Injury/pathology [MESH]Involvement of heparanase in the pathogenesis of acute kidney injury: (epmc).pdf DeepDyve Pubget Overpricing